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Ankfy1 ankyrin repeat and FYVE domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303292, updated on 30-Jul-2025
Official Symbol
Ankfy1provided by RGD
Official Full Name
ankyrin repeat and FYVE domain containing 1provided by RGD
Primary source
RGD:1309598
See related
Ensembl:ENSRNOG00000016212 AllianceGenome:RGD:1309598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol phosphate binding activity and small GTPase binding activity. Predicted to be involved in cytosolic transport; endosomal vesicle fusion; and positive regulation of pinocytosis. Predicted to be located in early endosome; macropinosome; and membrane. Predicted to be part of retromer complex. Predicted to be active in endosome membrane. Orthologous to human ANKFY1 (ankyrin repeat and FYVE domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 172.5), Lung (RPKM 166.9) and 9 other tissues See more
Orthologs
human mouse all
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See Ankfy1 in Genome Data Viewer
Location:
10q24
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (57810781..57882495)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57312246..57383964)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59259955..59331669)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2G 1 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene ribosomal protein L17, pseudogene 5 Neighboring gene cytochrome b5 domain containing 2 Neighboring gene zinc finger ZZ-type and EF-hand domain containing 1 Neighboring gene ribosomal protein S27, pseudogene 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Characterization and chromosomal mapping of a novel human gene, ANKHZN. Kuriyama H, et al. Gene, 2000 Aug 8. PMID 10940552
  2. Molecular cloning of a novel 130-kDa cytoplasmic protein, Ankhzn, containing Ankyrin repeats hooked to a zinc finger motif. Ito K, et al. Biochem Biophys Res Commun, 1999 Apr 2. PMID 10092534
  3. RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor. Nehru V, et al. Traffic, 2013 Dec. PMID 24102721
  4. Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. Zhang J, et al. Traffic, 2012 May. PMID 22284051, Free PMC Article
  5. The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms. Schnatwinkel C, et al. PLoS Biol, 2004 Sep. PMID 15328530, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pinocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in macropinosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
rabankyrin-5
Names
ankyrin repeat and FYVE domain-containing protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107018.2 → NP_001100488.2  rabankyrin-5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5Y6Q8, D4A1J6
    Related
    ENSRNOP00000021816.6, ENSRNOT00000021816.8
    Conserved Domains (8) summary
    smart00225
    Location:69 → 156
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:167 → 235
    BACK; BTB And C-terminal Kelch
    cd00204
    Location:866 → 992
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd15728
    Location:1101 → 1163
    FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
    pfam00651
    Location:61 → 156
    BTB; BTB/POZ domain
    pfam12796
    Location:875 → 969
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:353 → 408
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:726 → 767
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    57810781..57882495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086000.1 → XP_038941928.1  rabankyrin-5 isoform X1

    UniProtKB/TrEMBL
    A6HGG6
    Conserved Domains (6) summary
    PHA03095
    Location:544 → 835
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:391 → 590
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd15728
    Location:943 → 1005
    FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
    sd00045
    Location:568 → 609
    ANK; ANK repeat [structural motif]
    cd18501
    Location:4 → 92
    BACK_ANKFY1_Rank5; BACK (BTB and C-terminal Kelch) domain found in rabankyrin-5 (Rank-5)
    cl39094
    Location:149 → 411
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_039086001.2 → XP_038941929.1  rabankyrin-5 isoform X1

    UniProtKB/TrEMBL
    A6HGG6
    Conserved Domains (6) summary
    PHA03095
    Location:544 → 835
    PHA03095; ankyrin-like protein; Provisional
    COG0666
    Location:391 → 590
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd15728
    Location:943 → 1005
    FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
    sd00045
    Location:568 → 609
    ANK; ANK repeat [structural motif]
    cd18501
    Location:4 → 92
    BACK_ANKFY1_Rank5; BACK (BTB and C-terminal Kelch) domain found in rabankyrin-5 (Rank-5)
    cl39094
    Location:149 → 411
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version

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