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Ulk2 unc-51 like autophagy activating kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303206, updated on 6-Jul-2026
Official Symbol
Ulk2provided by RGD
Official Full Name
unc-51 like autophagy activating kinase 2provided by RGD
Primary source
RGD:1310181
See related
Ensembl:ENSRNOG00000002763 AllianceGenome:RGD:1310181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including axon extension; macroautophagy; and negative regulation of collateral sprouting. Predicted to act upstream of or within axon guidance; protein localization; and somatic sensory system development. Predicted to be active in autophagosome; cytosol; and phagophore assembly site membrane. Orthologous to human ULK2 (unc-51 like autophagy activating kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Muscle (RPKM 159.8), Lung (RPKM 151.5) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Ulk2 in Genome Data Viewer
Location:
10q22
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46951038..47029844, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (46451578..46530462, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 10 Neighboring gene scaffolding CK1 anchoring protein G Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene U6 spliceosomal RNA Neighboring gene A-kinase anchoring protein 10 Neighboring gene uncharacterized LOC134480803 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. Hara T, et al. J Cell Biol, 2008 May 5. PMID 18443221, Free PMC Article
  2. Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Zhou X, et al. Proc Natl Acad Sci U S A, 2007 Apr 3. PMID 17389358, Free PMC Article
  3. Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M. Hansen MD, et al. Proc Natl Acad Sci U S A, 2017 Apr 25. PMID 28389568, Free PMC Article
  4. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Chan EY, et al. Mol Cell Biol, 2009 Jan. PMID 18936157, Free PMC Article
  5. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z, et al. Curr Opin Cell Biol, 2010 Apr. PMID 20034776, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in axon extension IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon extension IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within axon extension ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within intracellular protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of collateral sprouting IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of collateral sprouting ISO
Inferred from Sequence Orthology
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in somatic sensory system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somatic sensory system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagophore assembly site membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
serine/threonine-protein kinase ULK2
Names
Unc-51 like kinase 2
NP_001178574.1
XP_006246559.1
XP_063125079.1
XP_063125080.1
XP_063125081.1
XP_063125082.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191645.2 → NP_001178574.1  serine/threonine-protein kinase ULK2

    See identical proteins and their annotated locations for NP_001178574.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0ABK0LAL8, D3Z9J7
    Related
    ENSRNOP00000003792.4, ENSRNOT00000003792.8
    Conserved Domains (2) summary
    cd14201
    Location:2 → 272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:843 → 1030
    DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    46951038..47029844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269011.1 → XP_063125081.1  serine/threonine-protein kinase ULK2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A395, A0ABK0LAL8
    Related
    ENSRNOP00000086173.1, ENSRNOT00000117957.2

  2. XM_063269010.1 → XP_063125080.1  serine/threonine-protein kinase ULK2 isoform X3

    UniProtKB/TrEMBL
    A0ABK0LAL8

  3. XM_006246497.5 → XP_006246559.1  serine/threonine-protein kinase ULK2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALB0, A0ABK0LAL8
    Related
    ENSRNOP00000094584.1, ENSRNOT00000102303.2
    Conserved Domains (3) summary
    smart00220
    Location:9 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14201
    Location:2 → 272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:865 → 1052
    DUF3543; Domain of unknown function (DUF3543)

  4. XM_063269009.1 → XP_063125079.1  serine/threonine-protein kinase ULK2 isoform X1

    UniProtKB/TrEMBL
    A0ABK0LAL8

  5. XM_063269012.1 → XP_063125082.1  serine/threonine-protein kinase ULK2 isoform X5

    UniProtKB/TrEMBL
    A0ABK0LAL8

RNA

  1. XR_010055178.1 RNA Sequence

  2. XR_005489813.2 RNA Sequence

  3. XR_005489812.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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