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Map2k3 mitogen activated protein kinase kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303200, updated on 5-Jan-2022

Summary

Symbol
Map2k3provided by RGD
Full Name
mitogen activated protein kinase kinase 3provided by RGD
Primary source
RGD:1306620
See related
Ensembl:ENSRNOG00000065992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mek3; Mkk3
Summary
Predicted to enable MAP kinase kinase activity and protein kinase binding activity. Involved in several processes, including cellular response to sorbitol; positive regulation of macromolecule metabolic process; and response to ischemia. Located in cytosol. Used to study retinal disease. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Muscle (RPKM 210.1), Spleen (RPKM 164.9) and 9 other tissues See more
Orthologs
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Genomic context

See Map2k3 in Genome Data Viewer
Location:
10q22
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45608145..45629492)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45089455..45110802)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546946 Neighboring gene uncharacterized LOC103693340 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 12 Neighboring gene SRA stem-loop-interacting RNA-binding protein, mitochondrial-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to sorbitol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 3
Names
dual specificity mitogen-activated protein kinase kinase 3-like
NP_001094144.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100674.1NP_001094144.1  dual specificity mitogen-activated protein kinase kinase 3

    See identical proteins and their annotated locations for NP_001094144.1

    Status: VALIDATED

    Source sequence(s)
    BC100095, BC160839, DY311082
    UniProtKB/TrEMBL
    B1H230, Q498S1
    Related
    ENSRNOP00000065373.2, ENSRNOT00000073792.3
    Conserved Domains (2) summary
    cd06617
    Location:62344
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    smart00220
    Location:67325
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    45608145..45629492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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