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Guk1 guanylate kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303179, updated on 19-Sep-2024

Summary

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Official Symbol
Guk1provided by RGD
Official Full Name
guanylate kinase 1provided by RGD
Primary source
RGD:1309638
See related
EnsemblRapid:ENSRNOG00000002928 AllianceGenome:RGD:1309638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables guanylate kinase activity. Involved in several processes, including glycoprotein transport; nucleobase-containing small molecule metabolic process; and nucleotide phosphorylation. Located in cytosol. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 210.0), Heart (RPKM 194.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44471075..44488332, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (43971514..43988658, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45535617..45552455, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly factor IBA57 Neighboring gene gap junction protein, gamma 2 Neighboring gene mitochondrial ribosomal protein L55 Neighboring gene similar to human chromosome 1 open reading frame 35 Neighboring gene ADP-ribosylation factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A microsomal GTPase is required for glycopeptide export from the mammalian endoplasmic reticulum. Ali BR, et al. J Biol Chem, 2000 Oct 27. PMID 10913137
  2. Structural characterization of the closed conformation of mouse guanylate kinase. Sekulic N, et al. J Biol Chem, 2002 Aug 16. PMID 12036965
  3. 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication. Field AK, et al. Proc Natl Acad Sci U S A, 1983 Jul. PMID 6306664, Free PMC Article
  4. Partial purification and properties of ATP:GMP phosphransferase from rat liver. Buccino RJ Jr, et al. Arch Biochem Biophys, 1969 Jun. PMID 4307347
  5. Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer. Khan N, et al. J Biol Chem, 2019 Aug 2. PMID 31201273, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables guanylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside monophosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GDP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GDP-mannose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dATP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dGDP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dGDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dGMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycoprotein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
guanylate kinase
Names
ATP:GMP-phosphotransferase
NP_001013133.2
XP_006246539.1
XP_063125059.1
XP_063125060.1
XP_063125061.1
XP_063125062.1
XP_063125063.1
XP_063125064.1
XP_063125065.1
XP_063125066.1
XP_063125067.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013115.3 → NP_001013133.2  guanylate kinase

    See identical proteins and their annotated locations for NP_001013133.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZT32, A6HEY0
    Related
    ENSRNOP00000003926.7, ENSRNOT00000003926.8
    Conserved Domains (2) summary
    TIGR03263
    Location:26 → 208
    guanyl_kin; guanylate kinase
    pfam00625
    Location:24 → 209
    Guanylate_kin; Guanylate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    44471075..44488332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268991.1 → XP_063125061.1  guanylate kinase isoform X4

    UniProtKB/TrEMBL
    Q71RR7

  2. XM_063268992.1 → XP_063125062.1  guanylate kinase isoform X4

    UniProtKB/TrEMBL
    Q71RR7

  3. XM_063268990.1 → XP_063125060.1  guanylate kinase isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZT32, A0A8I6GLP0

  4. XM_006246477.5 → XP_006246539.1  guanylate kinase isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZT32, A0A8I6A2B3
    Conserved Domains (2) summary
    TIGR03263
    Location:73 → 255
    guanyl_kin; guanylate kinase
    pfam00625
    Location:71 → 256
    Guanylate_kin; Guanylate kinase

  5. XM_063268995.1 → XP_063125065.1  guanylate kinase isoform X7

  6. XM_063268993.1 → XP_063125063.1  guanylate kinase isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZT32

  7. XM_063268989.1 → XP_063125059.1  guanylate kinase isoform X1

  8. XM_063268996.1 → XP_063125066.1  guanylate kinase isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZT32

  9. XM_063268994.1 → XP_063125064.1  guanylate kinase isoform X6

  10. XM_063268997.1 → XP_063125067.1  guanylate kinase isoform X9

Nucleotide Protein Strain
Heading Accession and Version

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