apoeb apolipoprotein Eb [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: apoebprovided by ZNC
Official Full Name: apolipoprotein Ebprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-368
See related: Ensembl:ENSDARG00000040295 AllianceGenome:ZFIN:ZDB-GENE-980526-368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: apoe; cb82; zeh1311; hm:zeh1311; wu:fa03d06; wu:fa97a11; wu:fc95h12; wu:fj54e06
Summary: Predicted to enable several functions, including cholesterol transfer activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in several processes, including cholesterol efflux; phospholipid efflux; and triglyceride-rich lipoprotein particle clearance. Predicted to act upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular matrix and extracellular space. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in several structures, including epidermis; fin bud; hematopoietic cell; median fin; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	16	NC_133191.1 (25253887..25256738)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (23960744..23963595)

Chromosome 16 - NC_133191.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Induction of apolipoprotein Eb (apoeb) and up-regulation of estrogen receptor 2a (esr2a) transcripts were observed in the epidermis at initiator sites of zebrafish ectodermal/dermal appendage morphogenesis.
Title: Epidermal transient down-regulation of retinol-binding protein 4 and mirror expression of apolipoprotein Eb and estrogen receptor 2a during zebrafish fin and scale development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fa96d02.x1 (e-PCR)
- UniSTS:202605

fa97a11.x1 (e-PCR)
- UniSTS:202613

fj54e06.x1 (e-PCR)
- UniSTS:199548

Z11376 (e-PCR)
- UniSTS:204676

fa03d06.s1 (e-PCR)
- UniSTS:202167

fk71d01.x1 (e-PCR)
- UniSTS:201458

fc95h12.x1 (e-PCR)
- UniSTS:204026

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cholesterol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables heparan sulfate proteoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in acylglycerol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chylomicron remnant clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in high-density lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intermediate-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in very-low-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular vesicle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
part_of intermediate-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
part_of low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of low-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: apolipoprotein Eb

Names: ApoE-2; apo-Eb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.