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Jade2 jade family PHD finger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303113, updated on 5-Jul-2025
Official Symbol
Jade2provided by RGD
Official Full Name
jade family PHD finger 2provided by RGD
Primary source
RGD:1309152
See related
Ensembl:ENSRNOG00000004956 AllianceGenome:RGD:1309152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Phf15
Summary
Predicted to enable histone H4 acetyltransferase activity and ubiquitin protein ligase activity. Predicted to contribute to histone H3K14 acetyltransferase activity. Predicted to be involved in regulation of cell cycle and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within neuron projection extension; positive regulation of neurogenesis; and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of histone acetyltransferase complex. Orthologous to human JADE2 (jade family PHD finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Adrenal (RPKM 66.3), Spleen (RPKM 52.7) and 9 other tissues See more
Orthologs
human mouse all
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See Jade2 in Genome Data Viewer
Location:
10q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36576187..36625129, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (36075239..36124210, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (37269132..37315638, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SEC24 homolog A, COPII coat complex component Neighboring gene small nuclear ribonucleoprotein F-like Neighboring gene secretion associated, Ras related GTPase 1B Neighboring gene uncharacterized LOC134480688 Neighboring gene proteasome 20S subunit beta 3, pseudogene 9 Neighboring gene uncharacterized LOC134480788

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development. Han X, et al. Mol Cell, 2014 Aug 7. PMID 25018020
  2. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. Redshaw N, et al. PLoS One, 2013. PMID 23390484, Free PMC Article
  3. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Doyon Y, et al. Mol Cell, 2006 Jan 6. PMID 16387653
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables histone H4K16 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron projection extension ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
E3 ubiquitin-protein ligase Jade-2
Names
PHD finger protein 15
protein Jade-2
NP_001100468.1
XP_006246316.2
XP_006246319.1
XP_006246320.1
XP_006246322.1
XP_017452741.1
XP_038941851.1
XP_038941852.1
XP_063125042.1
XP_063125043.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106998.3 → NP_001100468.1  E3 ubiquitin-protein ligase Jade-2

    See identical proteins and their annotated locations for NP_001100468.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HE78, G3V9F5
    Related
    ENSRNOP00000099332.1, ENSRNOT00000165733.1
    Conserved Domains (3) summary
    PHA03247
    Location:604 → 780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137 → 506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cl22851
    Location:254 → 364
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    36576187..36625129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268972.1 → XP_063125042.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    UniProtKB/TrEMBL
    A6HE78, G3V9F5

  2. XM_006246254.5 → XP_006246316.2  E3 ubiquitin-protein ligase Jade-2 isoform X1

    See identical proteins and their annotated locations for XP_006246316.2

    Conserved Domains (4) summary
    cd15680
    Location:201 → 246
    PHD_JADE2; PHD finger found in protein Jade-2 and similar proteins
    pfam10513
    Location:137 → 175
    EPL1; Enhancer of polycomb-like
    cl11396
    Location:660 → 746
    Patatin_and_cPLA2; Patatins and Phospholipases
    cl22851
    Location:254 → 364
    PHD_SF; PHD finger superfamily

  3. XM_006246257.5 → XP_006246319.1  E3 ubiquitin-protein ligase Jade-2 isoform X1

    See identical proteins and their annotated locations for XP_006246319.1

    Conserved Domains (4) summary
    cd15680
    Location:201 → 246
    PHD_JADE2; PHD finger found in protein Jade-2 and similar proteins
    pfam10513
    Location:137 → 175
    EPL1; Enhancer of polycomb-like
    cl11396
    Location:660 → 746
    Patatin_and_cPLA2; Patatins and Phospholipases
    cl22851
    Location:254 → 364
    PHD_SF; PHD finger superfamily

  4. XM_017597252.3 → XP_017452741.1  E3 ubiquitin-protein ligase Jade-2 isoform X1

    Related
    ENSRNOP00000045638.4, ENSRNOT00000043343.5
    Conserved Domains (4) summary
    cd15680
    Location:201 → 246
    PHD_JADE2; PHD finger found in protein Jade-2 and similar proteins
    pfam10513
    Location:137 → 175
    EPL1; Enhancer of polycomb-like
    cl11396
    Location:660 → 746
    Patatin_and_cPLA2; Patatins and Phospholipases
    cl22851
    Location:254 → 364
    PHD_SF; PHD finger superfamily

  5. XM_039085924.2 → XP_038941852.1  E3 ubiquitin-protein ligase Jade-2 isoform X3

    Conserved Domains (4) summary
    PHA03247
    Location:676 → 852
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:209 → 578
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    pfam10513
    Location:82 → 247
    EPL1; Enhancer of polycomb-like
    cl22851
    Location:326 → 436
    PHD_SF; PHD finger superfamily

  6. XM_039085923.2 → XP_038941851.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    UniProtKB/TrEMBL
    A6HE78, G3V9F5
    Conserved Domains (3) summary
    PHA03247
    Location:604 → 780
    PHA03247; large tegument protein UL36; Provisional
    COG5141
    Location:137 → 506
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cl22851
    Location:254 → 364
    PHD_SF; PHD finger superfamily

  7. XM_006246258.5 → XP_006246320.1  E3 ubiquitin-protein ligase Jade-2 isoform X1

    See identical proteins and their annotated locations for XP_006246320.1

    Conserved Domains (4) summary
    cd15680
    Location:201 → 246
    PHD_JADE2; PHD finger found in protein Jade-2 and similar proteins
    pfam10513
    Location:137 → 175
    EPL1; Enhancer of polycomb-like
    cl11396
    Location:660 → 746
    Patatin_and_cPLA2; Patatins and Phospholipases
    cl22851
    Location:254 → 364
    PHD_SF; PHD finger superfamily

  8. XM_063268973.1 → XP_063125043.1  E3 ubiquitin-protein ligase Jade-2 isoform X2

    UniProtKB/TrEMBL
    A6HE78, G3V9F5
    Related
    ENSRNOP00000103578.1, ENSRNOT00000171455.1

  9. XM_006246260.5 → XP_006246322.1  E3 ubiquitin-protein ligase Jade-2 isoform X1

    See identical proteins and their annotated locations for XP_006246322.1

    Conserved Domains (4) summary
    cd15680
    Location:201 → 246
    PHD_JADE2; PHD finger found in protein Jade-2 and similar proteins
    pfam10513
    Location:137 → 175
    EPL1; Enhancer of polycomb-like
    cl11396
    Location:660 → 746
    Patatin_and_cPLA2; Patatins and Phospholipases
    cl22851
    Location:254 → 364
    PHD_SF; PHD finger superfamily
Nucleotide Protein Strain
Heading Accession and Version

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