her4.5 hairy-related 4, tandem duplicate 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: her4.5provided by ZNC
Official Full Name: hairy-related 4, tandem duplicate 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-081031-106
See related: Ensembl:ENSDARG00000056729 AllianceGenome:ZFIN:ZDB-GENE-081031-106
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb74d11; si:ch73-21g5.6
Summary: Acts upstream of or within peripheral nervous system neuron axonogenesis. Is expressed in several structures, including anterior neural keel; hindbrain neural plate; immature eye; nervous system; and neural tube. [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

Location:: chromosome: 23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	23	NC_133198.1 (24380272..24382093, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (21469203..21471024, complement)

Chromosome 23 - NC_133198.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

her4 is involved in a replenishing pathway that maintains populations of stem cells in the central retina, and that the magnitude of the her4-associated proliferative response mirrors the extent of retinal damage.
Title: Tracking the fate of her4 expressing cells in the regenerating retina using her4:Kaede zebrafish.
At later stages her4 expression becomes Notch-dependent in the future sensory domains but loss of her4 does not result in hair cell overproduction, suggesting that there other her genes can compensate its function.
Title: The role of her4 in inner ear development and its relationship with proneural genes and Notch signalling.
Her4-positive cells are GFAP-positive in the adult brain of zebrafish
Title: Her4-positive population in the tectum opticum is proliferating neural precursors in the adult zebrafish brain.
These observations suggest that Her4 and Notch play a role in peripheral outgrowth of sensory neurons.
Title: Her4 is necessary for establishing peripheral projections of the trigeminal ganglia in zebrafish.
her4 may be differently regulated in sensory cranial ganglia, where Notch activity is not essential for her4 expression and where Su(H) may repress her4 expression
Title: Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos.
Results show that Her6 and Her4 are Notch signalling effectors that feedback on the clock and take part in the maintenance of cyclic gene expression coordination among adjacent cells in the presomitic mesoderm.
Title: Two zebrafish Notch-dependent hairy/Enhancer-of-split-related genes, her6 and her4, are required to maintain the coordination of cyclic gene expression in the presomitic mesoderm.

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General gene information

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Markers

fe26g04.x1 (e-PCR)
- UniSTS:196361

fc22h04.y1 (e-PCR)
- UniSTS:193118

her4 (e-PCR), detects polymorphism
- UniSTS:238283

fb74d11.x1 (e-PCR)
- UniSTS:191202

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within peripheral nervous system neuron axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: hairy-related 4, tandem duplicate 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131090.4 → NP_571165.3 hairy-related 4, tandem duplicate 5

Status: VALIDATED

Source sequence(s)

JBMGRA010000023

UniProtKB/TrEMBL

A0A8M1PAJ0, B0V3D4

Related

ENSDARP00000094981.3, ENSDART00000104206.4

Conserved Domains (2) summary

smart00511
Location:77 → 123

ORANGE; Orange domain

cd00083
Location:19 → 75

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...