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Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302983, updated on 5-Jan-2022

Summary

Official Symbol
Mapk8ip3provided by RGD
Official Full Name
mitogen-activated protein kinase 8 interacting protein 3provided by RGD
Primary source
RGD:1563691
See related
Ensembl:ENSRNOG00000033568
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
JIP3; JIP-3; JSAP1
Summary
Enables mitogen-activated protein kinase kinase binding activity. Involved in several processes, including anterograde axonal protein transport; axon regeneration; and positive regulation of JNK cascade. Located in several cellular components, including cell body; dendrite; and perinuclear region of cytoplasm. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Brain (RPKM 323.6), Thymus (RPKM 124.3) and 9 other tissues See more
Orthologs
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Genomic context

See Mapk8ip3 in Genome Data Viewer
Location:
10q12
Exon count:
34
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13918417..13958335, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14259394..14299276, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3 Neighboring gene Jupiter microtubule associated homolog 2 Neighboring gene cramped chromatin regulator homolog 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables JUN kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP-kinase scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in anterograde axonal protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterograde axonal protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in axon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axolemma ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-Jun-amino-terminal kinase-interacting protein 3
Names
JNK MAP kinase scaffold protein 3
JNK-interacting protein 3
JNK/SAPK-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100673.1NP_001094143.1  C-Jun-amino-terminal kinase-interacting protein 3

    See identical proteins and their annotated locations for NP_001094143.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ377222
    UniProtKB/TrEMBL
    B0VXR4
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:411479
    JIP_LZII; JNK-interacting protein leucine zipper II

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    13918417..13958335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245962.3XP_006246024.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X11

    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:385453
    JIP_LZII; JNK-interacting protein leucine zipper II
  2. XM_006245958.3XP_006246020.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X7

    Related
    ENSRNOP00000089458.1, ENSRNOT00000101875.1
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:410478
    JIP_LZII; JNK-interacting protein leucine zipper II
  3. XM_006245956.3XP_006246018.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X5

    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:416484
    JIP_LZII; JNK-interacting protein leucine zipper II
  4. XM_006245963.3XP_006246025.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X12

    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:380448
    JIP_LZII; JNK-interacting protein leucine zipper II
  5. XM_006245961.3XP_006246023.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X10

    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:386454
    JIP_LZII; JNK-interacting protein leucine zipper II
  6. XM_006245955.4XP_006246017.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X4

    See identical proteins and their annotated locations for XP_006246017.1

    Related
    ENSRNOP00000039682.4, ENSRNOT00000042066.4
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:417485
    JIP_LZII; JNK-interacting protein leucine zipper II
  7. XM_006245960.4XP_006246022.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X9

    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:393461
    JIP_LZII; JNK-interacting protein leucine zipper II
  8. XM_006245954.3XP_006246016.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X2

    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:424492
    JIP_LZII; JNK-interacting protein leucine zipper II
  9. XM_006245959.4XP_006246021.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X8

    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:394462
    JIP_LZII; JNK-interacting protein leucine zipper II
  10. XM_008767567.2XP_008765789.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X3

    Related
    ENSRNOP00000096061.1, ENSRNOT00000109512.1
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:419487
    JIP_LZII; JNK-interacting protein leucine zipper II
  11. XM_006245957.3XP_006246019.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X6

    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:425493
    JIP_LZII; JNK-interacting protein leucine zipper II
  12. XM_006245953.3XP_006246015.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X1

    Related
    ENSRNOP00000082502.1, ENSRNOT00000094258.1
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:425493
    JIP_LZII; JNK-interacting protein leucine zipper II
  13. XM_008767569.3XP_008765791.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X14

    Conserved Domains (2) summary
    pfam04871
    Location:173296
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam16471
    Location:163231
    JIP_LZII; JNK-interacting protein leucine zipper II
  14. XM_008767568.3XP_008765790.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform X13

    Conserved Domains (2) summary
    pfam04871
    Location:225348
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam16471
    Location:215283
    JIP_LZII; JNK-interacting protein leucine zipper II
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