U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

foxo3b forkhead box O3b [ Danio rerio (zebrafish) ]

Gene ID: 30296, updated on 2-Nov-2024

Summary

Official Symbol
foxo3bprovided by ZNC
Official Full Name
forkhead box O3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990708-6
See related
Ensembl:ENSDARG00000042904 AllianceGenome:ZFIN:ZDB-GENE-990708-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fkhr; foxo5; zFkhr; wu:fj65a12
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of defense response to virus; and primitive hemopoiesis. Predicted to be active in nucleus. Predicted to colocalize with mitochondrial matrix. Is expressed in several structures, including immune system; muscle; nervous system; pericardial region; and posterior lateral mesoderm. Orthologous to human FOXO3 (forkhead box O3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See foxo3b in Genome Data Viewer
Location:
chromosome: 20
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (32286783..32332736, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (32383904..32429857, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch211-51a19.5 Neighboring gene sestrin 1 Neighboring gene armadillo repeat containing 2 Neighboring gene AFG1 like ATPase b Neighboring gene sorting nexin 3

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
forkhead box protein O3B
Names
forkhead box O5
forkhead protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131085.1NP_571160.1  forkhead box protein O3B

    See identical proteins and their annotated locations for NP_571160.1

    Status: PROVISIONAL

    Source sequence(s)
    AF114262
    UniProtKB/TrEMBL
    Q9W7F8
    Related
    ENSDARP00000062981.3, ENSDART00000062982.4
    Conserved Domains (3) summary
    cd00059
    Location:127207
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16675
    Location:411489
    FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
    pfam16676
    Location:586624
    FOXO-TAD; Transactivation domain of FOXO protein family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    32286783..32332736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)