npy neuropeptide Y [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: npyprovided by ZNC
Official Full Name: neuropeptide Yprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-438
See related: Ensembl:ENSDARG00000036222 AllianceGenome:ZFIN:ZDB-GENE-980526-438
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-22m8.5
Summary: Enables type 2 neuropeptide Y receptor binding activity. Acts upstream of or within negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of circadian sleep/wake cycle, sleep; and positive regulation of feeding behavior. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; eye; immune system; and male organism. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; alcohol use disorder; artery disease (multiple); and epilepsy (multiple). Orthologous to human NPY (neuropeptide Y). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	19	NC_133194.1 (22511163..22513427, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (20111746..20114010, complement)

Chromosome 19 - NC_133194.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Convergent Energy State-Dependent Antagonistic Signaling by Cocaine- and Amphetamine-Regulated Transcript (CART) and Neuropeptide Y (NPY) Modulates the Plasticity of Forebrain Neurons to Regulate Feeding in Zebrafish.
Title: Convergent Energy State-Dependent Antagonistic Signaling by Cocaine- and Amphetamine-Regulated Transcript (CART) and Neuropeptide Y (NPY) Modulates the Plasticity of Forebrain Neurons to Regulate Feeding in Zebrafish.
Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models.
Title: Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models.
Sensitivity of olfactory sensory neurons to food cues is tuned to nutritional states by Neuropeptide Y signaling.
Title: Sensitivity of olfactory sensory neurons to food cues is tuned to nutritional states by Neuropeptide Y signaling.
Adequate expression of neuropeptide Y is essential for the recovery of zebrafish motor function following spinal cord injury.
Title: Adequate expression of neuropeptide Y is essential for the recovery of zebrafish motor function following spinal cord injury.
Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio).
Title: Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio).
Overexpression of NPY increases sleep, whereas mutation of npy or ablation of npy-expressing neurons decreases sleep. NPY regulates sleep primarily by modulating the length of wake bouts.
Title: Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling.
NPY acts as an orexigenic factor in the zebrafish.
Title: Neuropeptide Y stimulates food intake in the Zebrafish, Danio rerio.
Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties.(
Title: Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties.
In this study described the the lateral line presence of NPY-like immunoreactivity (IR) in of the Antarctic nototheniod fish. Differences in size and cellular composition between the two neuromasts were presen NPY immunoreactivity.
Title: First detection of neuropeptide Y (NPY)-like immunoreactivity in the lateral line: presence and distribution in the neuromasts of the Antarctic notothenioid fish Trematomus bernacchii.
This study suggest that NYP cells of nucleus entopeduncularis and nucleus preopticus periventricularis, and related fiber systems, might be involved in processing of sex steroid-borne information.
Title: Reproduction phase-related variations in neuropeptide Y immunoreactivity in the olfactory system, forebrain, and pituitary of the female catfish, Clarias batrachus (Linn.).

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General gene information

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Markers

fj53c02.y1 (e-PCR)
- UniSTS:199525

npy (e-PCR), detects polymorphism
- UniSTS:238287

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide Y receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 2 neuropeptide Y receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type 2 neuropeptide Y receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pro-neuropeptide Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.