Ace2 angiotensin converting enzyme 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ace2provided by RGD
Official Full Name: angiotensin converting enzyme 2provided by RGD
Primary source: RGD:728890
See related: Ensembl:ENSRNOG00000031665 AllianceGenome:RGD:728890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Located in extracellular space. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Kidney (RPKM 108.4), Lung (RPKM 75.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (33925458..33972851, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (30293597..30340961, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (32050734..32095860, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of angiotensin converting enzyme 2 promotes hippocampal neurogenesis via activation of Wnt/beta-catenin signaling in hypertension.
Title: Activation of angiotensin converting enzyme 2 promotes hippocampal neurogenesis via activation of Wnt/β-catenin signaling in hypertension.
SARS-CoV-2 Spike Protein Enhances Carboxypeptidase Activity of Angiotensin-Converting Enzyme 2.
Title: SARS-CoV-2 Spike Protein Enhances Carboxypeptidase Activity of Angiotensin-Converting Enzyme 2.
Sirt1 activation prevents high glucose-induced angiotensin converting enzyme 2 downregulation in renal tubular cells by regulating the TIMP3/ADAM17 pathway.
Title: Sirt1 activation prevents high glucose-induced angiotensin converting enzyme 2 downregulation in renal tubular cells by regulating the TIMP3/ADAM17 pathway.
Dietary fish intake increased the concentration of soluble ACE2 in rats: can fish consumption reduce the risk of COVID-19 infection through interception of SARS-CoV-2 by soluble ACE2?
Title: Dietary fish intake increased the concentration of soluble ACE2 in rats: can fish consumption reduce the risk of COVID-19 infection through interception of SARS-CoV-2 by soluble ACE2?
Genetically engineered Lactobacillus paracasei rescues colonic angiotensin converting enzyme 2 (ACE2) and attenuates hypertension in female Ace2 knock out rats.
Title: Genetically engineered Lactobacillus paracasei rescues colonic angiotensin converting enzyme 2 (ACE2) and attenuates hypertension in female Ace2 knock out rats.
ACE and ACE2 catalytic activity in the fecal content along the gut.
Title: ACE and ACE2 catalytic activity in the fecal content along the gut.
ACE2 inhibits proliferation of smooth muscle cell through AT1R and its downstream signaling pathway.
Title: ACE2 inhibits proliferation of smooth muscle cell through AT1R and its downstream signaling pathway.
ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19.
Title: ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19.
Klotho restoration via ACE2 activation: A potential therapeutic strategy against acute kidney injury-diabetes comorbidity.
Title: Klotho restoration via ACE2 activation: A potential therapeutic strategy against acute kidney injury-diabetes comorbidity.
ACE2 gene combined with exercise training attenuates central AngII/AT1 axis function and oxidative stress in a prehypertensive rat model.
Title: ACE2 gene combined with exercise training attenuates central AngII/AT1 axis function and oxidative stress in a prehypertensive rat model.

Submit: New GeneRIF Correction See all GeneRIFs (112)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
NOT enables carboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables carboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-dipeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-dipeptidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transporter activator activity	IEA Inferred from Electronic Annotation more info
enables transporter activator activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	IEA Inferred from Electronic Annotation more info
NOT enables virus receptor activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiotensin maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiotensin maturation	IEA Inferred from Electronic Annotation more info
involved_in angiotensin maturation	ISO Inferred from Sequence Orthology more info
involved_in angiotensin-mediated drinking behavior	IEA Inferred from Electronic Annotation more info
involved_in angiotensin-mediated drinking behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ceramide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in entry receptor-mediated virion attachment to host cell	IEA Inferred from Electronic Annotation more info
involved_in entry receptor-mediated virion attachment to host cell	ISO Inferred from Sequence Orthology more info
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of L-proline import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of L-proline import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gap junction assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gap junction assembly	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated virion attachment to host cell	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated virion attachment to host cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by renin-angiotensin	IEA Inferred from Electronic Annotation more info
involved_in regulation of systemic arterial blood pressure by renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in tryptophan transport	IEA Inferred from Electronic Annotation more info
involved_in tryptophan transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: angiotensin-converting enzyme 2

Names: ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; renal angiotensin-converting enzyme 2

NP_001012006.1

EC 3.4.17.23

XP_038955582.1

EC 3.4.17.23

XP_038955583.1

EC 3.4.17.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012006.2 → NP_001012006.1 angiotensin-converting enzyme 2 precursor

See identical proteins and their annotated locations for NP_001012006.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q5EGZ1

UniProtKB/TrEMBL

A0A0G2JXU8, C7ECU5

Related

ENSRNOP00000070410.2, ENSRNOT00000080730.3

Conserved Domains (2) summary

pfam01401
Location:22 → 606

Peptidase_M2; Angiotensin-converting enzyme

pfam16959
Location:617 → 746

Collectrin; Renal amino acid transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

33925458..33972851 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099655.2 → XP_038955583.1 angiotensin-converting enzyme 2 isoform X1

UniProtKB/Swiss-Prot

Q5EGZ1

UniProtKB/TrEMBL

A0A0G2JXU8, C7ECU5

Conserved Domains (2) summary

pfam01401
Location:22 → 606

Peptidase_M2; Angiotensin-converting enzyme

pfam16959
Location:617 → 746

Collectrin; Renal amino acid transporter
XM_039099654.2 → XP_038955582.1 angiotensin-converting enzyme 2 isoform X1

UniProtKB/Swiss-Prot

Q5EGZ1

UniProtKB/TrEMBL

A0A0G2JXU8, C7ECU5

Conserved Domains (2) summary

pfam01401
Location:22 → 606

Peptidase_M2; Angiotensin-converting enzyme

pfam16959
Location:617 → 746

Collectrin; Renal amino acid transporter