dkk1b dickkopf WNT signaling pathway inhibitor 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dkk1bprovided by ZNC
Official Full Name: dickkopf WNT signaling pathway inhibitor 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990708-5
See related: Ensembl:ENSDARG00000045219 AllianceGenome:ZFIN:ZDB-GENE-990708-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dkk1
Summary: Predicted to enable co-receptor binding activity and receptor antagonist activity. Involved in endocardial cushion development and heart valve development. Acts upstream of or within several processes, including hepaticobiliary system development; negative regulation of canonical Wnt signaling pathway; and sensory epithelium regeneration. Located in cytoplasm and extracellular region. Is expressed in several structures, including embryonic structure; median fin fold; mesoderm; pharyngeal arch; and sensory system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	12	NC_133187.1 (7012046..7014161)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (6465556..6467675)

Chromosome 12 - NC_133187.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that redistribution of cytosolic beta-catenin by Dkk1 concomitantly drives repression of cell adhesion and inhibits beta-catenin-dependent transcriptional output
Title: Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd and subsequent maintenance of dkk1b expression levels.
Title: Chordin and dickkopf-1b are essential for the formation of head structures through activation of the FGF signaling pathway in zebrafish.
Kremen1 modulates Wnt activity by restricting the range of secreted Dkk proteins during collective cell migration in the posterior lateral line primordium
Title: Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish.
Neuromast size is controlled by a balance between growth-promoting Wnt signaling activity in proliferation-competent cells and Wnt-inhibiting Dkk activity produced by differentiated sensory cells.
Title: Wnt/Dkk negative feedback regulates sensory organ size in zebrafish.
Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles on the surfaces of adult male zebrafish pectoral fins
Title: Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins.
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt signaling inhibitor, Dkk, and induced expression of the Wnt ligand, Wnt4a.
Title: Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration.

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General gene information

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Markers

dkk1 (e-PCR), detects polymorphism
- UniSTS:205651

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables co-receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell dedifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ectoderm development	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within endocardial cushion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocardial cushion development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within forebrain neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart valve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatic duct development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within notochord development	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within posterior lateral line neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sensory epithelium regeneration	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dickkopf-related protein 1b

Names: dickkopf 1; dickkopf 1b; dickkopf-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.