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wnt10a wingless-type MMTV integration site family, member 10a [ Danio rerio (zebrafish) ]

Gene ID: 30171, updated on 6-Jul-2026
Official Symbol
wnt10aprovided by ZNC
Official Full Name
wingless-type MMTV integration site family, member 10aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-278
See related
Ensembl:ENSDARG00000017155 AllianceGenome:ZFIN:ZDB-GENE-990415-278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
WNT-10A
Summary
Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within odontogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in caudal fin and nervous system. Human ortholog(s) of this gene implicated in Schopf-Schulz-Passarge syndrome; ectodermal dysplasia; and tooth agenesis. Orthologous to human WNT10A (Wnt family member 10A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See wnt10a in Genome Data Viewer
Location:
chromosome: 9
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 9 NC_133184.1 (11506765..11534579)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 9 NC_007120.7 (11379859..11409691)

Chromosome 9 - NC_133184.1Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor a Neighboring gene wingless-type MMTV integration site family, member 6b Neighboring gene cyclin dependent kinase 5, regulatory subunit 2b (p39) Neighboring gene microRNA mir-1788 Neighboring gene FEV transcription factor, ETS family member

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. V-ATPase proton pumping activity is required for adult zebrafish appendage regeneration. Monteiro J, et al. PLoS One, 2014. PMID 24671205, Free PMC Article
  2. Polarization and migration in the zebrafish posterior lateral line system. Knutsdottir H, et al. PLoS Comput Biol, 2017 Apr. PMID 28369079, Free PMC Article
  3. Role of WNT10A in failure of tooth development in humans and zebrafish. Yuan Q, et al. Mol Genet Genomic Med, 2017 Nov. PMID 29178643, Free PMC Article
  4. Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways. Tang D, et al. Front Mol Neurosci, 2016. PMID 27303264, Free PMC Article
  5. Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration. Garland MA, et al. Toxicol Rep, 2019. PMID 31249786, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis.
    Title: wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within odontogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
protein Wnt-10a
Names
etID309718.9

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130980.2 → NP_571055.1  protein Wnt-10a

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000009
    UniProtKB/Swiss-Prot
    P43446
    UniProtKB/TrEMBL
    A0A8N1Z0N8, B0V1G8
    Related
    ENSDARP00000005680.8, ENSDART00000007308.9
    Conserved Domains (1) summary
    cd19355
    Location:95 → 442
    Wnt_Wnt10a; Wnt domain found in protein Wnt-10a and similar proteins

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133184.1 Reference GRCz12tu Primary Assembly

    Range
    11506765..11534579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43446.1 GenPept UniProtKB/Swiss-Prot:P43446

Gene LinkOut

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