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Prkag3 protein kinase AMP-activated non-catalytic subunit gamma 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301518, updated on 11-Apr-2024

Summary

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Official Symbol
Prkag3provided by RGD
Official Full Name
protein kinase AMP-activated non-catalytic subunit gamma 3provided by RGD
Primary source
RGD:1308698
See related
Ensembl:ENSRNOG00000017248 AllianceGenome:RGD:1308698
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ampkg3
Summary
Contributes to AMP-activated protein kinase activity. Predicted to be involved in cellular response to glucose starvation; protein phosphorylation; and regulation of catalytic activity. Predicted to act upstream of or within glycogen biosynthetic process; glycolytic process; and response to muscle activity involved in regulation of muscle adaptation. Part of nucleotide-activated protein kinase complex. Orthologous to human PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 168.9), Heart (RPKM 18.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
9q33
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83744385..83753629, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76295715..76304959, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81999368..82008620, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase like 4 Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1 Neighboring gene peptidylprolyl isomerase A, pseudogene 15 Neighboring gene Wnt family member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hypoxia-Induced Upregulation of miR-132 Promotes Schwann Cell Migration After Sciatic Nerve Injury by Targeting PRKAG3. Yao C, et al. Mol Neurobiol, 2016 Oct. PMID 26399639
  2. Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle. Mahlapuu M, et al. Am J Physiol Endocrinol Metab, 2004 Feb. PMID 14559719
  3. 5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics. Barnes BR, et al. FASEB J, 2005 May. PMID 15857891
  4. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, et al. FEBS Lett, 2003 Jul 3. PMID 12829246
  5. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG. J Cell Sci, 2004 Nov 1. PMID 15509864

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-132 downregulated PRKAG3 through binding to its 3'-UTR, and PRKAG3 knockdown compromised the reducing effect of miR-132 inhibition on Schwann cell migration under normal or hypoxia condition.
    Title: Hypoxia-Induced Upregulation of miR-132 Promotes Schwann Cell Migration After Sciatic Nerve Injury by Targeting PRKAG3.
  2. the observation that the AMPKgamma3 isoform is expressed primarily in white skeletal muscle, in which it is the predominant gamma-isoform, strongly suggests that gamma3 has a key role in this tissue.
    Title: Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to AMP-activated protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to AMP-activated protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycolytic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of catalytic activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to muscle activity involved in regulation of muscle adaptation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
5'-AMP-activated protein kinase subunit gamma-3
Names
AMP-activated protein kinase gamma 3 subunit
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
protein kinase, AMP-activated, gamma 3 non-catatlytic subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106921.1 → NP_001100391.1  5'-AMP-activated protein kinase subunit gamma-3

    See identical proteins and their annotated locations for NP_001100391.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474004
    UniProtKB/TrEMBL
    A6JVW1, D4A7E4
    Related
    ENSRNOP00000023365.5, ENSRNOT00000023365.6
    Conserved Domains (3) summary
    COG0517
    Location:361 → 478
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:201 → 334
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:361 → 480
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    83744385..83753629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266978.1 → XP_063123048.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X2

  2. XM_039083362.1 → XP_038939290.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X1

    Conserved Domains (2) summary
    cd04618
    Location:192 → 329
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:355 → 478
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  3. XM_039083363.2 → XP_038939291.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X3

    Conserved Domains (2) summary
    cd04618
    Location:167 → 304
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:330 → 453
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  4. XM_039083364.2 → XP_038939292.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X4

    Conserved Domains (2) summary
    cd04618
    Location:1 → 111
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:137 → 260
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
Nucleotide Protein Strain
Heading Accession and Version

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