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Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301458, updated on 22-Jan-2023

Summary

Official Symbol
Ndufs1provided by RGD
Official Full Name
NADH:ubiquinone oxidoreductase core subunit S1provided by RGD
Primary source
RGD:1359670
See related
Ensembl:ENSRNOG00000011849 AllianceGenome:RGD:1359670
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and electron transfer activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in several processes, including mitochondrial electron transport, NADH to ubiquinone; mitochondrion organization; and regulation of mitochondrial membrane potential. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 2953.4), Muscle (RPKM 1677.3) and 8 other tissues See more
Orthologs
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Genomic context

See Ndufs1 in Genome Data Viewer
Location:
9q32
Exon count:
19
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (64546430..64579751, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (69919863..69953182, complement)

Chromosome 9 - NC_051344.1Genomic Context describing neighboring genes Neighboring gene INO80 complex subunit D Neighboring gene NOP16 nucleolar protein, pseudogene 2 Neighboring gene small nucleolar RNA SNORD51 Neighboring gene small nucleolar RNA SNORA41 Neighboring gene eukaryotic translation elongation factor 1 beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93795

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
 
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to NADH dehydrogenase (ubiquinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables NADH dehydrogenase (ubiquinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ATP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic mitochondrial changes ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic mitochondrial changes ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in cellular respiration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular respiration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrial electron transport, NADH to ubiquinone ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial electron transport, NADH to ubiquinone ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Names
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa
NP_001005550.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005550.1NP_001005550.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001005550.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081892
    UniProtKB/Swiss-Prot
    Q66HF1
    Related
    ENSRNOP00000087012.1, ENSRNOT00000104288.1
    Conserved Domains (1) summary
    PRK09130
    Location:31723
    PRK09130; NADH dehydrogenase subunit G; Validated

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051344.1 Reference mRatBN7.2 Primary Assembly

    Range
    64546430..64579751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)