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Cdk15 cyclin-dependent kinase 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301440, updated on 5-Mar-2024

Summary

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Official Symbol
Cdk15provided by RGD
Official Full Name
cyclin-dependent kinase 15provided by RGD
Primary source
RGD:1306205
See related
Ensembl:ENSRNOG00000022899 AllianceGenome:RGD:1306205
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fzd7
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle. Orthologous to human CDK15 (cyclin dependent kinase 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 6.1), Testes (RPKM 3.1) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdk15 in Genome Data Viewer
Location:
9q31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (68205759..68299218)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60710787..60803638)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (66059765..66153729)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene alsin Rho guanine nucleotide exchange factor ALS2 Neighboring gene uncharacterized LOC134480372 Neighboring gene ribosomal protein S2, pseudogene 15 Neighboring gene uncharacterized LOC134480290 Neighboring gene uncharacterized LOC134480373

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34. Park MH, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24866247
  2. The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells. Brynczka C, et al. Differentiation, 2008 Sep. PMID 18177422, Free PMC Article
  3. Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition. Li CM, et al. Am J Pathol, 2002 Jun. PMID 12057921, Free PMC Article
  4. Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Yu H, et al. Development, 2012 Dec 1. PMID 23095888, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 15
Names
frizzled family receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    68205759..68299218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084848.2 → XP_038940776.1  cyclin-dependent kinase 15 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:104 → 285
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039084845.2 → XP_038940773.1  cyclin-dependent kinase 15 isoform X1

    UniProtKB/TrEMBL
    M0R7D0
    Conserved Domains (1) summary
    cd07870
    Location:104 → 389
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

  3. XM_039084847.2 → XP_038940775.1  cyclin-dependent kinase 15 isoform X1

    UniProtKB/TrEMBL
    M0R7D0
    Related
    ENSRNOP00000065356.3
    Conserved Domains (1) summary
    cd07870
    Location:104 → 389
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
Nucleotide Protein Strain
Heading Accession and Version

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