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dld deltaD [ Danio rerio (zebrafish) ]

Gene ID: 30138, updated on 29-Jan-2023

Summary

Official Symbol
dldprovided by ZNC
Official Full Name
deltaDprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-47
See related
Ensembl:ENSDARG00000020219 AllianceGenome:ZFIN:ZDB-GENE-990415-47
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sc:d0402
Summary
Enables PDZ domain binding activity. Acts upstream of or within several processes, including animal organ development; lateral inhibition; and regulation of hematopoietic stem cell differentiation. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including gut; mesoderm; nervous system; presumptive mesoderm; and tail bud. Orthologous to human DLL1 (delta like canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See dld in Genome Data Viewer
Location:
chromosome: 13
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (6075572..6081803, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (5947112..5953343, complement)
103 previous assembly Zv9 (GCF_000002035.4) 13 NC_007124.5 (5753087..5759318, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene actin related protein 2b Neighboring gene PHD finger protein 10 Neighboring gene family with sequence similarity 120B Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1G

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC158216

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables PDZ domain binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Notch signaling pathway TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within determination of left/right symmetry IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of liver left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of pancreatic left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within hematopoietic stem cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lateral inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sclerotome development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within somatic motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventral spinal cord interneuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ventral spinal cord interneuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IGI
Inferred from Genetic Interaction
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
delta-like protein D
Names
aei
after eight protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130955.2NP_571030.2  delta-like protein D precursor

    See identical proteins and their annotated locations for NP_571030.2

    Status: PROVISIONAL

    Source sequence(s)
    BC129159
    UniProtKB/TrEMBL
    A1L1P2
    Related
    ENSDARP00000089996.3, ENSDART00000099224.4
    Conserved Domains (3) summary
    smart00051
    Location:157219
    DSL; delta serrate ligand
    cd00054
    Location:327362
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07657
    Location:2090
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    6075572..6081803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)