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dla deltaA [ Danio rerio (zebrafish) ]

Gene ID: 30131, updated on 29-Jan-2023

Summary

Official Symbol
dlaprovided by ZNC
Official Full Name
deltaAprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-29
See related
Ensembl:ENSDARG00000010791 AllianceGenome:ZFIN:ZDB-GENE-980526-29
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb335; fa04c10; wu:fa04c10
Summary
Predicted to enable Notch binding activity. Acts upstream of or within several processes, including animal organ development; floor plate development; and regulation of Notch signaling pathway. Located in cell cortex and plasma membrane. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural plate; and neural tube. Orthologous to human DLL1 (delta like canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See dla in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (54013455..54026180)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (53353712..53366437)
103 previous assembly Zv9 (GCF_000002035.4) 1 NC_007112.5 (54580037..54592933)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene centriole, cilia and spindle-associated protein a Neighboring gene si:ch211-133l11.10 Neighboring gene TRIO and F-actin binding protein a Neighboring gene single-pass membrane protein with aspartate-rich tail 1b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within diencephalon development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within diencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within floor plate development IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within hypochord development IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within inner ear receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural crest cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within notochord cell differentiation IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventral spinal cord interneuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ventral spinal cord interneuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
delta-like protein A
Names
delta A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130954.2NP_571029.2  delta-like protein A precursor

    Status: VALIDATED

    Source sequence(s)
    AL929114
    UniProtKB/TrEMBL
    A0A8M1PA93, F1R7K3
    Related
    ENSDARP00000013374.6, ENSDART00000012104.8
    Conserved Domains (3) summary
    smart00051
    Location:161223
    DSL; delta serrate ligand
    cd00054
    Location:331366
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07657
    Location:2394
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    54013455..54026180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)