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H2AC7 H2A clustered histone 7 [ Homo sapiens (human) ]

Gene ID: 3013, updated on 25-Nov-2021

Summary

Official Symbol
H2AC7provided by HGNC
Official Full Name
H2A clustered histone 7provided by HGNC
Primary source
HGNC:HGNC:4729
See related
Ensembl:ENSG00000196866 MIM:602792
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2A.3; H2A/g; H2AFG; HIST1H2AD
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2AC7 in Genome Data Viewer
Location:
6p22.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (26198784..26199293, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26199012..26199521, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 4 Neighboring gene H1.12 linker histone, cluster member, pseudogene Neighboring gene H3 clustered histone 4 Neighboring gene H2B clustered histone 7 Neighboring gene ribosomal protein S10 pseudogene 1

Genomic regions, transcripts, and products

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: H3C4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H2A type 1-D
Names
H2A histone family, member G
histone 1, H2ad
histone H2A.3
histone H2A/g
histone H2AD
histone cluster 1 H2A family member d
histone cluster 1, H2ad

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021065.3NP_066409.1  histone H2A type 1-D

    See identical proteins and their annotated locations for NP_066409.1

    Status: REVIEWED

    Source sequence(s)
    AL031777
    Consensus CDS
    CCDS4591.1
    UniProtKB/Swiss-Prot
    P20671
    UniProtKB/TrEMBL
    B2R5B6
    Related
    ENSP00000341094.2, ENST00000341023.2
    Conserved Domains (1) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    26198784..26199293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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