Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uqcrc1provided by RGD
Official Full Name: ubiquinol-cytochrome c reductase core protein 1provided by RGD
Primary source: RGD:1303314
See related: Ensembl:ENSRNOG00000032134 AllianceGenome:RGD:1303314
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin protein ligase binding activity. Involved in response to activity and response to alkaloid. Located in mitochondrion. Part of mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 3760.7), Muscle (RPKM 2441.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109589735..109601481)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117679328..117691073)

Chromosome 8 - NC_051343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquinol-cytochrome c reductase core protein 1 overexpression protects H9c2 cardiac cells against mimic ischemia/reperfusion injury through PI3K/Akt/GSK-3beta pathway.
Title: Ubiquinol-cytochrome c reductase core protein 1 overexpression protects H9c2 cardiac cells against mimic ischemia/reperfusion injury through PI3K/Akt/GSK-3β pathway.
the overexpression of UQCRC1 can protect H9c2 cardiac cells against simulated ischemia/reperfusion, and this cardio-protective effect is likely mediated by zinc binding.
Title: Overexpression of Ubiquinol-Cytochrome c Reductase Core Protein 1 May Protect H9c2 Cardiac Cells by Binding with Zinc.
These results showed that UQCRC1 might contribute to the loss-of-cardioprotection model induced by long-term diazoxide treatment and play a role in delayed cardioprotection.
Title: Ubiquinol-cytochrome c reductase core protein 1 may be involved in delayed cardioprotection from preconditioning induced by diazoxide.
reduced expression in myocardial mitochondria after TNF administration
Title: TNF-induced mitochondrial damage: a link between mitochondrial complex I activity and left ventricular dysfunction.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Uqcrc1 gene: The Uqcrc1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, C.elegans, and frog.
Orthologs from Annotation Pipeline: 471 organisms have orthologs with human gene Uqcrc1
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mitochondrial electron transport, ubiquinol to cytochrome c	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex III	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial respiratory chain complex III	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome b-c1 complex subunit 1, mitochondrial

Names: complex III subunit 1; core protein I; ubiquinol-cytochrome c reductase core protein I; ubiquinol-cytochrome-c reductase complex core protein 1

NP_001004250.1

EC 7.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004250.2 → NP_001004250.1 cytochrome b-c1 complex subunit 1, mitochondrial precursor

See identical proteins and their annotated locations for NP_001004250.1

Status: PROVISIONAL

Source sequence(s)

BC078923

UniProtKB/Swiss-Prot

Q68FY0

Related

ENSRNOP00000044696.2, ENSRNOT00000042114.5

Conserved Domains (1) summary

COG0612
Location:46 → 469

PqqL; Predicted Zn-dependent peptidase [General function prediction only]