Ifrd2 interferon-related developmental regulator 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ifrd2provided by RGD
Official Full Name: interferon-related developmental regulator 2provided by RGD
Primary source: RGD:1310222
See related: Ensembl:ENSRNOG00000016150 AllianceGenome:RGD:1310222
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ribosome binding activity and translation repressor activity. Predicted to be involved in negative regulation of translation. Predicted to act upstream of or within several processes, including Wnt signaling pathway; adipose tissue development; and fat cell differentiation. Orthologous to human IFRD2 (interferon related developmental regulator 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Muscle (RPKM 119.6), Spleen (RPKM 117.9) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8q32

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117139612..117144834)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108260969..108266191)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116343096..116348318)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

BF407105 (e-PCR)
- UniSTS:248589

AI838527 (e-PCR)
- UniSTS:164418

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables translation repressor activity	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adipose tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adipose tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: interferon-related developmental regulator 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047871.1 → NP_001041336.1 interferon-related developmental regulator 2

See identical proteins and their annotated locations for NP_001041336.1

Status: PROVISIONAL

Source sequence(s)

DQ480751

UniProtKB/TrEMBL

A0A8I6A4D6, A6I2Y9, B1WBM5, Q0ZFS6

Related

ENSRNOP00000022092.5, ENSRNOT00000022092.7

Conserved Domains (2) summary

pfam04836
Location:385 → 438

IFRD_C; Interferon-related protein conserved region

pfam05004
Location:32 → 340

IFRD; Interferon-related developmental regulator (IFRD)