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Hyal3 hyaluronidase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300993, updated on 18-Apr-2019

Summary

Official Symbol
Hyal3provided by RGD
Official Full Name
hyaluronidase 3provided by RGD
Primary source
RGD:1303334
See related
Ensembl:ENSRNOG00000016093
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
member of a family of enzymes that catalyze the breakdown of the extracellular matrix component hyaluronan [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 99.8), Lung (RPKM 53.9) and 9 other tissues See more
Orthologs

Genomic context

See Hyal3 in Genome Data Viewer
Location:
8q32
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116336512..116342147)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (115692772..115698407)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene hyaluronidase 2 Neighboring gene hyaluronidase 1 Neighboring gene N(alpha)-acetyltransferase 80, NatH catalytic subunit Neighboring gene interferon-related developmental regulator 2 Neighboring gene leucine-rich single-pass membrane protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
hyaluronoglucuronidase activity IEA
Inferred from Electronic Annotation
more info
 
hyaluronoglucuronidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
hyalurononglucosaminidase activity IEA
Inferred from Electronic Annotation
more info
 
hyalurononglucosaminidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT hyalurononglucosaminidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
hyalurononglucosaminidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT virus receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cartilage development ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to UV-B IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
PubMed 
hyaluronan catabolic process IEA
Inferred from Electronic Annotation
more info
 
hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
hyaluronan catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ovarian follicle development ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of ovarian follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
ovarian follicle atresia IEA
Inferred from Electronic Annotation
more info
 
ovarian follicle atresia ISO
Inferred from Sequence Orthology
more info
PubMed 
ovarian follicle atresia ISS
Inferred from Sequence or Structural Similarity
more info
 
penetration of zona pellucida IEA
Inferred from Electronic Annotation
more info
 
penetration of zona pellucida ISO
Inferred from Sequence Orthology
more info
PubMed 
penetration of zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of acrosomal vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of acrosomal vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of acrosomal vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
response to antibiotic ISO
Inferred from Sequence Orthology
more info
PubMed 
response to virus IEA
Inferred from Electronic Annotation
more info
 
response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
acrosomal membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
acrosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
sperm midpiece IEA
Inferred from Electronic Annotation
more info
 
sperm midpiece ISO
Inferred from Sequence Orthology
more info
PubMed 
sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
hyaluronidase-3
Names
hyal-3
hyaluronoglucosaminidase 3
NP_997482.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207599.2NP_997482.2  hyaluronidase-3 precursor

    See identical proteins and their annotated locations for NP_997482.2

    Status: PROVISIONAL

    Source sequence(s)
    BC097259
    UniProtKB/Swiss-Prot
    Q76HM9
    UniProtKB/TrEMBL
    A0A0G2JSP4
    Related
    ENSRNOP00000021590.3, ENSRNOT00000021590.4
    Conserved Domains (1) summary
    pfam01630
    Location:26350
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    116336512..116342147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    107560963..107566598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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