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hhex hematopoietically expressed homeobox [ Danio rerio (zebrafish) ]

Gene ID: 30098, updated on 9-Sep-2025
Official Symbol
hhexprovided by ZNC
Official Full Name
hematopoietically expressed homeoboxprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-299
See related
AllianceGenome:ZFIN:ZDB-GENE-980526-299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hex
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including hemangioblast cell differentiation; liver morphogenesis; and regionalization. Acts upstream of or within with a positive effect on hepaticobiliary system development. Acts upstream of or within several processes, including circulatory system development; exocrine pancreas development; and positive regulation of endothelial cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; endocrine system; hepatoblast; and mesoderm. Orthologous to human HHEX (hematopoietically expressed homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Annotation information
Annotation category: suggests misassembly
Orthologs
human mouse all
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See hhex in Genome Data Viewer
Location:
chromosome: 12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 12 NC_133187.1 (49857974..49869826)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 12 NC_007123.7 (47663395..47670491)

Chromosome 12 - NC_133187.1Genomic Context describing neighboring genes Neighboring gene fumarate hydratase Neighboring gene uncharacterized LOC141376892 Neighboring gene uncharacterized LOC141376893 Neighboring gene ras-related protein Rab-37

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Regulation of hhex expression in the yolk syncytial layer, the potential Nieuwkoop center homolog in zebrafish. Bischof J, et al. Dev Biol, 2004 Dec 15. PMID 15581885
  2. Liver specification: a new role for Wnts in liver development. Burke ZD, et al. Curr Biol, 2006 Sep 5. PMID 16950093
  3. Bmp2 signaling regulates the hepatic versus pancreatic fate decision. Chung WS, et al. Dev Cell, 2008 Nov. PMID 19000838, Free PMC Article
  4. Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors. Elsalini OA, et al. Dev Biol, 2003 Nov 1. PMID 14568547
  5. Igf2bp1 is required for hepatic outgrowth during early liver development in zebrafish. Wu J, et al. Gene, 2020 Jun 20. PMID 32240777

See all (143) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish.
    Title: Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish.
  2. Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration.
    Title: Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration.
  3. Hhex regulates the specification and growth of the hepatopancreatic ductal system.
    Title: Hhex regulates the specification and growth of the hepatopancreatic ductal system.
  4. Hhex, Cdx1b, Pdx1, and Sox9b form a genetic network governing the patterning and morphogenesis of the HPD and digestive tract systems in zebrafish.
    Title: Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1.
  5. Overall, the data show that HHEX controls blood vessel and lymphatic vessel formation by regulating the VEGFC/FLT4/PROX1 signaling axis.
    Title: HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.
  6. hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
    Title: Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
  7. Data suggest that zebrafish hhex appears to be activated by Wnt/beta-catenin in the dorsal yolk syncytial layer, where bozozok acts in a permissive way to limit repression of hhex by Vega1 and Vega2.
    Title: Regulation of hhex expression in the yolk syncytial layer, the potential Nieuwkoop center homolog in zebrafish.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
  
involved_in digestive tract development IMP
Inferred from Mutant Phenotype
more info
  
involved_in dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
  
involved_in embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemangioblast cell differentiation IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within_positive_effect hepaticobiliary system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
  
involved_in liver development IMP
Inferred from Mutant Phenotype
more info
  
involved_in liver morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
  
acts_upstream_of_or_within positive regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thyroid gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
hematopoietically-expressed homeobox protein hhex
Names
homeobox protein hex

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130934.1 → NP_571009.1  hematopoietically-expressed homeobox protein hhex

    See identical proteins and their annotated locations for NP_571009.1

    Status: PROVISIONAL

    Source sequence(s)
    AF131070
    UniProtKB/Swiss-Prot
    Q9IAV3
    Conserved Domains (1) summary
    pfam00046
    Location:123 → 173
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133187.1 Reference GRCz12tu Primary Assembly

    Range
    49857974..49869826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9IAV3.1 GenPept UniProtKB/Swiss-Prot:Q9IAV3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials