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H1-4 H1.4 linker histone, cluster member [ Homo sapiens (human) ]

Gene ID: 3008, updated on 1-Jun-2020

Summary

Official Symbol
H1-4provided by HGNC
Official Full Name
H1.4 linker histone, cluster memberprovided by HGNC
Primary source
HGNC:HGNC:4718
See related
Ensembl:ENSG00000168298 MIM:142220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1E; H1.4; H1F4; RMNS; H1s-4; HIST1H1E; dJ221C16.5
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Orthologs

Genomic context

See H1-4 in Genome Data Viewer
Location:
6p22.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (26156329..26157115)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26156559..26157343)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2B clustered histone 4 Neighboring gene H2A clustered histone 6 Neighboring gene H2B clustered histone 5 Neighboring gene LARP1 pseudogene 1 Neighboring gene H2B clustered histone 6

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
RAHMAN SYNDROME
MedGen: C4479637 OMIM: 617537 GeneReviews: Not available
not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2019-06-26)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2019-06-26)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Overexpression of NPM1 enhances HIV-1 Tat-mediated transactivation by reducing the histone H1 occupancy on the chromatinized template of HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC116819

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding IEA
Inferred from Electronic Annotation
more info
 
AMP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
chromatin DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
dATP binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H3-K27 trimethylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-K4 trimethylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
nucleosome positioning IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear euchromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H1.4
Names
H1 histone family, member 4
histone 1, H1e
histone H1b
histone H1s-4
histone cluster 1 H1 family member e
histone cluster 1, H1e

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005321.3NP_005312.1  histone H1.4

    See identical proteins and their annotated locations for NP_005312.1

    Status: REVIEWED

    Source sequence(s)
    AL353759
    Consensus CDS
    CCDS4586.1
    UniProtKB/Swiss-Prot
    P10412
    UniProtKB/TrEMBL
    A3R0T8
    Related
    ENSP00000307705.3, ENST00000304218.5
    Conserved Domains (1) summary
    pfam00538
    Location:38108
    Linker_histone; linker histone H1 and H5 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    26156329..26157115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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