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H1-4 H1.4 linker histone, cluster member [ Homo sapiens (human) ]

Gene ID: 3008, updated on 6-Nov-2022

Summary

Official Symbol
H1-4provided by HGNC
Official Full Name
H1.4 linker histone, cluster memberprovided by HGNC
Primary source
HGNC:HGNC:4718
See related
Ensembl:ENSG00000168298 MIM:142220; AllianceGenome:HGNC:4718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1E; H1.4; H1F4; RMNS; H1s-4; HIST1H1E; dJ221C16.5
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H1-4 in Genome Data Viewer
Location:
6p22.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26156329..26157115)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26024465..26025251)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26156557..26157343)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2B clustered histone 4 Neighboring gene H2A clustered histone 6 Neighboring gene Sharpr-MPRA regulatory region 13869 Neighboring gene H2B clustered histone 5 Neighboring gene LARP1 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Rahman syndrome
MedGen: C4479637 OMIM: 617537 GeneReviews: HIST1H1E Syndrome
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2022-07-27)

ClinGen Genome Curation Page
Haploinsufficency

No evidence available (Last evaluated 2022-07-27)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Overexpression of NPM1 enhances HIV-1 Tat-mediated transactivation by reducing the histone H1 occupancy on the chromatinized template of HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC116819

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables chromatin DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H3-K27 trimethylation IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3-K4 trimethylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H1.4
Names
H1 histone family, member 4
histone 1, H1e
histone H1b
histone H1s-4
histone cluster 1 H1 family member e
histone cluster 1, H1e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005321.3NP_005312.1  histone H1.4

    See identical proteins and their annotated locations for NP_005312.1

    Status: REVIEWED

    Source sequence(s)
    AL353759
    Consensus CDS
    CCDS4586.1
    UniProtKB/Swiss-Prot
    P10412, Q4VB25
    UniProtKB/TrEMBL
    A3R0T8
    Related
    ENSP00000307705.4, ENST00000304218.6
    Conserved Domains (1) summary
    cd00073
    Location:34114
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    26156329..26157115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    26024465..26025251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)