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Stoml1 stomatin like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300748, updated on 24-Jul-2025
Official Symbol
Stoml1provided by RGD
Official Full Name
stomatin like 1provided by RGD
Primary source
RGD:1559463
See related
Ensembl:ENSRNOG00000008530 AllianceGenome:RGD:1559463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559463
Summary
Predicted to enable ion channel inhibitor activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Orthologous to human STOML1 (stomatin like 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Brain (RPKM 90.1), Lung (RPKM 34.7) and 9 other tissues See more
Orthologs
human mouse all
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See Stoml1 in Genome Data Viewer
Location:
8q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (67557846..67565734)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (58661980..58669860)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (63037135..63045024)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480059 Neighboring gene PML nuclear body scaffold Neighboring gene lysyl oxidase-like 1 Neighboring gene ribosomal protein L38, pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. Kozlenkov A, et al. J Physiol, 2014 Feb 15. PMID 24247984, Free PMC Article
  2. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. Redshaw N, et al. PLoS One, 2013. PMID 23390484, Free PMC Article
  3. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ion channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ion channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
stomatin-like protein 1
Names
stomatin (EPB72)-like 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305238.1 → NP_001292167.1  stomatin-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J4Z9, D4A7E9
    Related
    ENSRNOP00000011383.5, ENSRNOT00000011383.9
    Conserved Domains (3) summary
    smart00244
    Location:77 → 217
    PHB; prohibitin homologues
    cd13436
    Location:94 → 224
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:304 → 395
    SCP2; SCP-2 sterol transfer family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    67557846..67565734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243184.5 → XP_006243246.1  stomatin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006243246.1

    UniProtKB/TrEMBL
    A6J4Z9
    Conserved Domains (3) summary
    smart00244
    Location:83 → 167
    PHB; prohibitin homologues
    pfam02036
    Location:254 → 345
    SCP2; SCP-2 sterol transfer family
    cl19107
    Location:79 → 174
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
Nucleotide Protein Strain
Heading Accession and Version

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