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Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300732, updated on 7-Apr-2025

Summary

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Official Symbol
Pstpip1provided by RGD
Official Full Name
proline-serine-threonine phosphatase-interacting protein 1provided by RGD
Primary source
RGD:1307557
See related
EnsemblRapid:ENSRNOG00000016413 AllianceGenome:RGD:1307557
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity; identical protein binding activity; and protein phosphatase binding activity. Predicted to be located in actin cytoskeleton; cleavage furrow; and cytosol. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in PAPA syndrome. Orthologous to human PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Thymus (RPKM 150.4), Spleen (RPKM 85.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pstpip1 in Genome Data Viewer
Location:
8q24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (65395328..65434616)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (56499287..56538593)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (60760040..60799364)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351848 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene tetraspanin 3 Neighboring gene ribosomal protein L17, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Yu JW, et al. Mol Cell, 2007 Oct 26. PMID 17964261, Free PMC Article
  2. PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase. Spencer S, et al. J Cell Biol, 1997 Aug 25. PMID 9265651, Free PMC Article
  3. Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL. Baum W, et al. J Biol Chem, 2005 Dec 2. PMID 16204241
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL
    Title: Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in actomyosin contractile ring ISO
Inferred from Sequence Orthology
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proline-serine-threonine phosphatase-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106824.2 → NP_001100294.2  proline-serine-threonine phosphatase-interacting protein 1

    See identical proteins and their annotated locations for NP_001100294.2

    Status: PROVISIONAL

    Source sequence(s)
    BC158859
    UniProtKB/TrEMBL
    B0BNK4
    Related
    ENSRNOP00000079186.1, ENSRNOT00000110505.2
    Conserved Domains (2) summary
    cd11824
    Location:363 → 415
    SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
    cl12013
    Location:16 → 257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    65395328..65434616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243113.5 → XP_006243175.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X1

    Conserved Domains (2) summary
    cd11824
    Location:360 → 412
    SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
    cl12013
    Location:16 → 257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_039081083.2 → XP_038937011.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X3

    Conserved Domains (2) summary
    cd11824
    Location:329 → 381
    SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
    cl12013
    Location:1 → 223
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_017595555.3 → XP_017451044.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    F7FFM6
    Related
    ENSRNOP00000061918.2, ENSRNOT00000063930.4

  4. XM_039081084.2 → XP_038937012.1  proline-serine-threonine phosphatase-interacting protein 1 isoform X4

    Conserved Domains (2) summary
    cd11824
    Location:241 → 293
    SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
    cl12013
    Location:1 → 135
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_005487766.2 RNA Sequence

  2. XR_005487765.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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