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Atm ATM serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 300711, updated on 18-Sep-2024

Summary

Official Symbol
Atmprovided by RGD
Official Full Name
ATM serine/threonine kinaseprovided by RGD
Primary source
RGD:1593265
See related
EnsemblRapid:ENSRNOG00000029773 AllianceGenome:RGD:1593265
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; phosphotransferase activity, alcohol group as acceptor; and protein N-terminus binding activity. Involved in several processes, including positive regulation of neuron apoptotic process; positive regulation of nitrogen compound metabolic process; and regulation of microglial cell activation. Located in cytoplasm and nucleus. Used to study ataxia telangiectasia; disease of cellular proliferation; infertility; leukemia; and lymphoma. Biomarker of pre-malignant neoplasm and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; endometrial cancer; lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 259.9), Thymus (RPKM 189.4) and 9 other tissues See more
Orthologs
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Genomic context

See Atm in Genome Data Viewer
Location:
8q24
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (62724939..62829040, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (53828741..53932773, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (58015938..58119973, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene protein O-glucosyltransferase 3 Neighboring gene similar to human chromosome 11 open reading frame 65 Neighboring gene uncharacterized LOC120094159 Neighboring gene nuclear protein, co-activator of histone transcription Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene acetyl-CoA acetyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA double-strand break processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within V(D)J recombination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to X-ray ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to nitrosative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of RNA localization to telomere ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein-containing complex localization to telomere ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within female gamete generation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within female gonad development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within female meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within meiotic telomere clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oocyte development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within peptidyl-serine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in pexophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomerase catalytic core complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in pre-B cell allelic exclusion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in replicative senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within thymus development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DNA repair complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine-protein kinase ATM
Names
Ataxia telangiectasia gene mutated in human beings
ataxia telangiectasia mutated homolog
NP_001100291.1
XP_008764444.1
XP_038936996.1
XP_038936997.1
XP_038936998.1
XP_038937000.1
XP_038937002.1
XP_063121184.1
XP_063121185.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106821.1NP_001100291.1  serine-protein kinase ATM

    See identical proteins and their annotated locations for NP_001100291.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473975
    UniProtKB/TrEMBL
    A6J4J4, D4ACL8
    Related
    ENSRNOP00000045529.3, ENSRNOT00000050555.5
    Conserved Domains (4) summary
    cd05171
    Location:26912970
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:21032497
    FAT; FAT domain
    pfam02260
    Location:30343063
    FATC; FATC domain
    pfam11640
    Location:11165
    TAN; Telomere-length maintenance and DNA damage repair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    62724939..62829040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081069.2XP_038936997.1  serine-protein kinase ATM isoform X1

    Conserved Domains (4) summary
    cd05171
    Location:27233002
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:21372529
    FAT; FAT domain
    pfam02260
    Location:30663095
    FATC; FATC domain
    pfam11640
    Location:8165
    TAN; Telomere-length maintenance and DNA damage repair
  2. XM_039081070.2XP_038936998.1  serine-protein kinase ATM isoform X1

    Conserved Domains (4) summary
    cd05171
    Location:27233002
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:21372529
    FAT; FAT domain
    pfam02260
    Location:30663095
    FATC; FATC domain
    pfam11640
    Location:8165
    TAN; Telomere-length maintenance and DNA damage repair
  3. XM_008766222.4XP_008764444.1  serine-protein kinase ATM isoform X2

    See identical proteins and their annotated locations for XP_008764444.1

    UniProtKB/TrEMBL
    A0A0G2K3I0
    Conserved Domains (4) summary
    cd05171
    Location:26892968
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:21032495
    FAT; FAT domain
    pfam02260
    Location:30323061
    FATC; FATC domain
    pfam11640
    Location:11165
    TAN; Telomere-length maintenance and DNA damage repair
  4. XM_039081068.2XP_038936996.1  serine-protein kinase ATM isoform X1

    Related
    ENSRNOP00000103895.1, ENSRNOT00000171802.1
    Conserved Domains (4) summary
    cd05171
    Location:27233002
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:21372529
    FAT; FAT domain
    pfam02260
    Location:30663095
    FATC; FATC domain
    pfam11640
    Location:8165
    TAN; Telomere-length maintenance and DNA damage repair
  5. XM_039081072.2XP_038937000.1  serine-protein kinase ATM isoform X3

    Conserved Domains (3) summary
    cd05171
    Location:21982477
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:16122004
    FAT; FAT domain
    pfam02260
    Location:25412570
    FATC; FATC domain
  6. XM_039081074.2XP_038937002.1  serine-protein kinase ATM isoform X4

    Conserved Domains (2) summary
    pfam02259
    Location:21372186
    FAT; FAT domain
    pfam11640
    Location:8165
    TAN; Telomere-length maintenance and DNA damage repair
  7. XM_063265114.1XP_063121184.1  serine-protein kinase ATM isoform X5

  8. XM_063265115.1XP_063121185.1  serine-protein kinase ATM isoform X6

RNA

  1. XR_005487761.2 RNA Sequence