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Atm ATM serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 300711, updated on 12-Aug-2018

Summary

Official Symbol
Atmprovided by RGD
Official Full Name
ATM serine/threonine kinaseprovided by RGD
Primary source
RGD:1593265
See related
Ensembl:ENSRNOG00000029773
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
serine/threonine protein kinase; critical regulator of the cellular DNA damage response [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 259.9), Thymus (RPKM 189.4) and 9 other tissues See more
Orthologs

Genomic context

See Atm in Genome Data Viewer
Location:
8q24
Exon count:
64
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (58015938..58119973, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (56598503..56703115, complement)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene KDEL motif containing 2 Neighboring gene similar to RIKEN cDNA 4930550C14 Neighboring gene nuclear protein, co-activator of histone transcription Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene acetyl-CoA acetyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
1-phosphatidylinositol-3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
 
DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
DNA damage induced protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
DNA damage induced protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA repair ISO
Inferred from Sequence Orthology
more info
 
V(D)J recombination ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
brain development ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to X-ray IEA
Inferred from Electronic Annotation
more info
 
cellular response to X-ray ISO
Inferred from Sequence Orthology
more info
 
cellular response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to nitrosative stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to nitrosative stress ISO
Inferred from Sequence Orthology
more info
 
chromosome organization involved in meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
establishment of RNA localization to telomere IEA
Inferred from Electronic Annotation
more info
 
establishment of RNA localization to telomere ISO
Inferred from Sequence Orthology
more info
 
female gamete generation ISO
Inferred from Sequence Orthology
more info
 
female gonad development ISO
Inferred from Sequence Orthology
more info
 
female meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
histone mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
histone phosphorylation IEA
Inferred from Electronic Annotation
more info
 
immune system process ISO
Inferred from Sequence Orthology
more info
 
immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
lipoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
 
male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
meiotic telomere clustering ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle assembly checkpoint IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomere capping IEA
Inferred from Electronic Annotation
more info
 
negative regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
oocyte development ISO
Inferred from Sequence Orthology
more info
 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomerase catalytic core complex assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomerase catalytic core complex assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance via telomere lengthening IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
pre-B cell allelic exclusion ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
 
regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
replicative senescence IEA
Inferred from Electronic Annotation
more info
 
replicative senescence ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
signal transduction involved in mitotic G2 DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
 
signal transduction involved in mitotic G2 DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
somitogenesis ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
thymus development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
DNA repair complex IEA
Inferred from Electronic Annotation
more info
 
DNA repair complex ISO
Inferred from Sequence Orthology
more info
 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine-protein kinase ATM
Names
Ataxia telangiectasia gene mutated in human beings
ataxia telangiectasia mutated homolog
NP_001100291.1
XP_006243130.1
XP_008764444.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106821.1NP_001100291.1  serine-protein kinase ATM

    See identical proteins and their annotated locations for NP_001100291.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473975
    UniProtKB/TrEMBL
    D4ACL8
    Related
    ENSRNOP00000045529.3, ENSRNOT00000050555.3
    Conserved Domains (4) summary
    cd05171
    Location:26912970
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:21032497
    FAT; FAT domain
    pfam02260
    Location:30343063
    FATC; FATC domain
    pfam11640
    Location:11165
    TAN; Telomere-length maintenance and DNA damage repair

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    58015938..58119973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243068.1XP_006243130.1  serine-protein kinase ATM isoform X1

    See identical proteins and their annotated locations for XP_006243130.1

    UniProtKB/TrEMBL
    A0A0G2K3I0
    Related
    ENSRNOP00000072646.1, ENSRNOT00000086812.1
    Conserved Domains (4) summary
    cd05171
    Location:26892968
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:21032495
    FAT; FAT domain
    pfam02260
    Location:30323061
    FATC; FATC domain
    pfam11640
    Location:11165
    TAN; Telomere-length maintenance and DNA damage repair
  2. XM_008766222.2XP_008764444.1  serine-protein kinase ATM isoform X1

    See identical proteins and their annotated locations for XP_008764444.1

    UniProtKB/TrEMBL
    A0A0G2K3I0
    Conserved Domains (4) summary
    cd05171
    Location:26892968
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:21032495
    FAT; FAT domain
    pfam02260
    Location:30323061
    FATC; FATC domain
    pfam11640
    Location:11165
    TAN; Telomere-length maintenance and DNA damage repair

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    53321802..53423212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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