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Arcn1 archain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300674, updated on 5-Sep-2025
Official Symbol
Arcn1provided by RGD
Official Full Name
archain 1provided by RGD
Primary source
RGD:1359110
See related
Ensembl:ENSRNOG00000061108 AllianceGenome:RGD:1359110
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in Golgi localization; endoplasmic reticulum to Golgi vesicle-mediated transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within several processes, including Golgi vesicle transport; adult locomotory behavior; and cerebellar Purkinje cell layer maturation. Predicted to be located in COPI-coated vesicle; Golgi apparatus; and endoplasmic reticulum. Predicted to be part of COPI vesicle coat. Orthologous to human ARCN1 (archain 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Liver (RPKM 556.7), Kidney (RPKM 502.1) and 9 other tissues See more
Orthologs
human mouse all
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See Arcn1 in Genome Data Viewer
Location:
8q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53954401..53979005, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45057617..45082224, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49051257..49075861, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094134 Neighboring gene pleckstrin homology-like domain, family B, member 1 Neighboring gene uncharacterized LOC134480161 Neighboring gene intraflagellar transport 46 Neighboring gene transmembrane protein 25 Neighboring gene tetratricopeptide repeat domain 36

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Mutation in archain 1, a subunit of COPI coatomer complex, causes diluted coat color and Purkinje cell degeneration. Xu X, et al. PLoS Genet, 2010 May 20. PMID 20502676, Free PMC Article
  2. Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. Hata S, et al. J Biol Chem, 2006 Apr 21. PMID 16476741
  3. In vivo assembly of coatomer, the COP-I coat precursor. Lowe M, et al. J Biol Chem, 1996 Nov 29. PMID 8940050
  4. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Orcl L, et al. Nature, 1993 Aug 19. PMID 8355790
  5. The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. Boutchueng-Djidjou M, et al. Mol Cell Proteomics, 2015 Apr. PMID 25687571, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP
    Title: Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC94158

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Golgi localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Golgi vesicle transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell layer maturation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell layer maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pigmentation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pigmentation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat IEA
Inferred from Electronic Annotation
more info
  
located_in COPI-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in COPI-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in COPI-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
coatomer subunit delta
Names
delta-COP
delta-coat protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007662.1 → NP_001007663.1  coatomer subunit delta

    See identical proteins and their annotated locations for NP_001007663.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081979
    UniProtKB/Swiss-Prot
    Q66H80
    UniProtKB/TrEMBL
    A0A8L2R622, A6J409
    Related
    ENSRNOP00000072654.3, ENSRNOT00000082687.3
    Conserved Domains (2) summary
    cd09254
    Location:272 → 508
    AP_delta-COPI_MHD; Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit
    cd14830
    Location:4 → 133
    Delta_COP_N; delta subunit of the F-COPI complex, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53954401..53979005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H80.1 GenPept UniProtKB/Swiss-Prot:Q66H80

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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