U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ei24 EI24, autophagy associated transmembrane protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 300514, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Ei24provided by RGD
Official Full Name
EI24, autophagy associated transmembrane proteinprovided by RGD
Primary source
RGD:1309868
See related
Ensembl:ENSRNOG00000030391 AllianceGenome:RGD:1309868
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable importin-alpha family protein binding activity. Predicted to be involved in macroautophagy. Predicted to act upstream of or within several processes, including cellular response to UV-C; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of protein import into nucleus. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in endoplasmic reticulum. Orthologous to human EI24 (EI24 autophagy associated transmembrane protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 381.9), Adrenal (RPKM 232.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ei24 in Genome Data Viewer
Location:
8q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (44683138..44699502, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (36494289..36510653, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39254883..39271238, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene checkpoint kinase 1 Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit A Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene 60S ribosomal protein L14 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival. Yuan L, et al. J Biol Chem, 2018 Jun 29. PMID 29769309, Free PMC Article
  2. The p53-induced gene Ei24 is an essential component of the basal autophagy pathway. Zhao YG, et al. J Biol Chem, 2012 Dec 7. PMID 23074225, Free PMC Article
  3. Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide. Mork CN, et al. FEBS Lett, 2007 Nov 27. PMID 17981155, Free PMC Article
  4. The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain. Lieu KG, et al. J Cell Biol, 2014 May 12. PMID 24821838, Free PMC Article
  5. Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation. Sung YH, et al. J Biol Chem, 2013 Oct 25. PMID 24014029, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic beta-cell survival
    Title: Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC112713

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables importin-alpha family protein binding IEA
Inferred from Electronic Annotation
more info
  
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to UV-C ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
etoposide-induced protein 2.4 homolog
Names
etoposide induced 2.4 mRNA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025660.1 → NP_001020831.1  etoposide-induced protein 2.4 homolog

    See identical proteins and their annotated locations for NP_001020831.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098721
    UniProtKB/Swiss-Prot
    Q4KM77
    UniProtKB/TrEMBL
    A0A8L2QNF3, A6KRM7
    Conserved Domains (1) summary
    pfam07264
    Location:120 → 254
    EI24; Etoposide-induced protein 2.4 (EI24)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    44683138..44699502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242800.5 → XP_006242862.1  etoposide-induced protein 2.4 homolog isoform X1

    See identical proteins and their annotated locations for XP_006242862.1

    UniProtKB/Swiss-Prot
    Q4KM77
    UniProtKB/TrEMBL
    A0A8L2QNF3, A6KRM7
    Conserved Domains (1) summary
    pfam07264
    Location:120 → 254
    EI24; Etoposide-induced protein 2.4 (EI24)

  2. XM_006242801.5 → XP_006242863.1  etoposide-induced protein 2.4 homolog isoform X1

    See identical proteins and their annotated locations for XP_006242863.1

    UniProtKB/Swiss-Prot
    Q4KM77
    UniProtKB/TrEMBL
    A0A8L2QNF3, A6KRM7
    Conserved Domains (1) summary
    pfam07264
    Location:120 → 254
    EI24; Etoposide-induced protein 2.4 (EI24)

  3. XM_039081024.2 → XP_038936952.1  etoposide-induced protein 2.4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q4KM77
    UniProtKB/TrEMBL
    A0A8L2QNF3, A6KRM7
    Related
    ENSRNOP00000078348.1
    Conserved Domains (1) summary
    pfam07264
    Location:120 → 254
    EI24; Etoposide-induced protein 2.4 (EI24)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KM77.1 GenPept UniProtKB/Swiss-Prot:Q4KM77

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous