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H1-0 H1.0 linker histone [ Homo sapiens (human) ]

Gene ID: 3005, updated on 5-Jul-2020

Summary

Official Symbol
H1-0provided by HGNC
Official Full Name
H1.0 linker histoneprovided by HGNC
Primary source
HGNC:HGNC:4714
See related
Ensembl:ENSG00000189060 MIM:142708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H10; H1.0; H1F0; H1FV
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Orthologs

Genomic context

See H1-0 in Genome Data Viewer
Location:
22q13.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (37805229..37807432)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38201114..38203443)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene TRIO and F-actin binding protein Neighboring gene uncharacterized LOC102724378 Neighboring gene Sharpr-MPRA regulatory region 8034 Neighboring gene glycine C-acetyltransferase Neighboring gene galanin receptor 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5241

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AT DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic DNA fragmentation TAS
Traceable Author Statement
more info
 
chromatin silencing IGI
Inferred from Genetic Interaction
more info
PubMed 
chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
nucleosome positioning IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H1.0
Names
H1 histone family member 0
H1.0, H1(0), H1-0
histone H1'
histone H1(0)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005318.4NP_005309.1  histone H1.0

    See identical proteins and their annotated locations for NP_005309.1

    Status: REVIEWED

    Source sequence(s)
    Z97630
    Consensus CDS
    CCDS13956.1
    UniProtKB/Swiss-Prot
    P07305
    Related
    ENSP00000344504.2, ENST00000340857.3
    Conserved Domains (1) summary
    pfam00538
    Location:2596
    Linker_histone; linker histone H1 and H5 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    37805229..37807432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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