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Dpy19l2 dpy-19 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300461, updated on 5-Sep-2025
Official Symbol
Dpy19l2provided by RGD
Official Full Name
dpy-19 like 2provided by RGD
Primary source
RGD:1564311
See related
Ensembl:ENSRNOG00000045585 AllianceGenome:RGD:1564311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dyp19l2; RGD1564311
Summary
Predicted to enable mannosyltransferase activity. Predicted to be involved in spermatid development. Predicted to be active in nuclear inner membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 9. Orthologous to human DPY19L2 (dpy-19 like 2). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Restricted expression toward (RPKM 375.0) See more
Orthologs
human mouse all
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See Dpy19l2 in Genome Data Viewer
Location:
8q13
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (31338450..31457682, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (23062592..23181817, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (25710492..25829589, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene dpy-19 like C-mannosyltransferase 1 Neighboring gene T-box transcription factor 20 Neighboring gene EH domain-containing protein 3-like

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus. Pierre V, et al. Development, 2012 Aug. PMID 22764053
  2. A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation. Harbuz R, et al. Am J Hum Genet, 2011 Mar 11. PMID 21397064, Free PMC Article
  3. DPY19L2 deletion as a major cause of globozoospermia. Koscinski I, et al. Am J Hum Genet, 2011 Mar 11. PMID 21397063, Free PMC Article
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
dpy-19 like 2; probable C-mannosyltransferase DPY19L2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429432.1 → NP_001416361.1  dpy-19 like 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AKU1, A0A8I6G8Q8

  2. NM_001429433.1 → NP_001416362.1  dpy-19 like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AKU1, M0RC58

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    31338450..31457682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_235972.11 → XP_235972.6  probable C-mannosyltransferase DPY19L2 isoform X2

    Related
    ENSRNOP00000067167.2, ENSRNOT00000071884.4
    Conserved Domains (1) summary
    pfam10034
    Location:130 → 771
    Dpy19; Q-cell neuroblast polarization

  2. XM_006242722.5 → XP_006242784.1  probable C-mannosyltransferase DPY19L2 isoform X1

    Related
    ENSRNOP00000083270.1, ENSRNOT00000111129.2
    Conserved Domains (1) summary
    pfam10034
    Location:130 → 788
    Dpy19; Q-cell neuroblast polarization
Nucleotide Protein Strain
Heading Accession and Version

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