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Opn4 opsin 4 (melanopsin) [ Mus musculus (house mouse) ]

Gene ID: 30044, updated on 17-Jan-2023

Summary

Official Symbol
Opn4provided by MGI
Official Full Name
opsin 4 (melanopsin)provided by MGI
Primary source
MGI:MGI:1353425
See related
Ensembl:ENSMUSG00000021799 AllianceGenome:MGI:1353425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm533; 1110007J02Rik
Summary
Enables G protein-coupled photoreceptor activity. Involved in several processes, including hyaloid vascular plexus regression; optokinetic behavior; and phototransduction. Acts upstream of or within several processes, including detection of temperature stimulus involved in thermoception; entrainment of circadian clock by photoperiod; and thermotaxis. Located in sperm head plasma membrane. Is expressed in eye and future brain. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 1.8), thymus adult (RPKM 0.2) and 3 other tissues See more
Orthologs
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Genomic context

See Opn4 in Genome Data Viewer
Location:
14; 14 B
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34312575..34322099, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34590618..34600142, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9230112D13 gene Neighboring gene LIM domain binding 3 Neighboring gene predicted gene, 52113 Neighboring gene RIKEN cDNA 5830448L01 gene Neighboring gene WAPL cohesin release factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 11-cis retinal binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled photoreceptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled photoreceptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables photoreceptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within detection of temperature stimulus involved in thermoception IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hyaloid vascular plexus regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in optokinetic behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phototransduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within thermotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sperm head plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128599.1NP_001122071.1  melanopsin isoform 2

    See identical proteins and their annotated locations for NP_001122071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region and 3' UTR. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC114543
    Consensus CDS
    CCDS49446.1
    UniProtKB/Swiss-Prot
    Q9QXZ9
    Related
    ENSMUSP00000126136.2, ENSMUST00000168444.9
    Conserved Domains (2) summary
    pfam00001
    Location:86347
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:77244
    7tm_4; Olfactory receptor
  2. NM_013887.2NP_038915.1  melanopsin isoform 1

    See identical proteins and their annotated locations for NP_038915.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AC114543
    Consensus CDS
    CCDS26943.1
    UniProtKB/Swiss-Prot
    B2C712, Q9QXZ9
    Related
    ENSMUSP00000022331.3, ENSMUST00000022331.3
    Conserved Domains (2) summary
    pfam00001
    Location:86347
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:77244
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    34312575..34322099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)