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MNS1 mannosyl-oligosaccharide 1,2-alpha-mannosidase [ Sugiyamaella lignohabitans ]

Gene ID: 30036763, updated on 25-Jan-2024

Summary

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Gene symbol
MNS1
Gene description
mannosyl-oligosaccharide 1,2-alpha-mannosidase
Locus tag
AWJ20_4611
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sugiyamaella lignohabitans (strain: CBS 10342, type-material: culture from holotype of Candida lignohabitans)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Trichomonascaceae; Sugiyamaella
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Genomic context

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See MNS1 in Genome Data Viewer
Location:
chromosome: D
Exon count:
1
Sequence:
Chromosome: D; NC_031673.1 (25250..27241, complement)

Chromosome D - NC_031673.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene allantoicase Neighboring gene peptidase family M20 protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_031673.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-glycan processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase
XP_018736145.1
  • Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8864657]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IEA,IEA]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IDA] [PMID 12090241]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IMP] [PMID 1714453]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IMP] [PMID 8439291]; GO_function: GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [Evidence IDA] [PMID 8910350]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 8905927]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0035977 - protein deglycosylation involved in glycoprotein catabolic process [Evidence IMP] [PMID 9732283]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_031673.1 Reference assembly

    Range
    25250..27241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018881693.1 → XP_018736145.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase [Sugiyamaella lignohabitans]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A167E5K1
Nucleotide Protein
Heading Accession and Version

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