Format

Send to:

Choose Destination

GZMK granzyme K [ Homo sapiens (human) ]

Gene ID: 3003, updated on 8-Dec-2018

Summary

Official Symbol
GZMKprovided by HGNC
Official Full Name
granzyme Kprovided by HGNC
Primary source
HGNC:HGNC:4711
See related
Ensembl:ENSG00000113088 MIM:600784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRYP2
Summary
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 65.9), spleen (RPKM 22.6) and 7 other tissues See more
Orthologs

Genomic context

See GZMK in Genome Data Viewer
Location:
5q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (55024279..55034132)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54320107..54329960)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene endothelial cell specific molecule 1 Neighboring gene uncharacterized LOC102467081 Neighboring gene uncharacterized LOC105378971 Neighboring gene granzyme A pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
granzyme K
Names
NK-Tryp-2
NK-tryptase-2
fragmentin-3
granzyme 3
granzyme K (granzyme 3; tryptase II)
granzyme K (serine protease, granzyme 3; tryptase II)
tryptase II
NP_002095.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002104.2NP_002095.1  granzyme K precursor

    See identical proteins and their annotated locations for NP_002095.1

    Status: REVIEWED

    Source sequence(s)
    BC035802
    Consensus CDS
    CCDS3964.1
    UniProtKB/Swiss-Prot
    P49863
    Related
    ENSP00000231009.2, ENST00000231009.2
    Conserved Domains (2) summary
    smart00020
    Location:26254
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:27257
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    55024279..55034132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center