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Sp7 Sp7 transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 300260, updated on 2-Oct-2018

Summary

Official Symbol
Sp7provided by RGD
Official Full Name
Sp7 transcription factorprovided by RGD
Primary source
RGD:631377
See related
Ensembl:ENSRNOG00000014082
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Osx
Summary
may act as a transcription factor; mouse homolog is required for bone formation and osteoblast differentiation [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 5.1), Uterus (RPKM 0.6) and 2 other tissues See more
Orthologs

Genomic context

See Sp7 in Genome Data Viewer
Location:
7q36
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143957316..143967488, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (141753826..141762790, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene melanocyte proliferating gene 1 Neighboring gene aladin WD repeat nucleoporin Neighboring gene Sp1 transcription factor Neighboring gene anti-Mullerian hormone receptor type 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor Sp7
Names
osterix

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037632.1NP_001032721.1  transcription factor Sp7 isoform 1

    See identical proteins and their annotated locations for NP_001032721.1

    Status: PROVISIONAL

    Source sequence(s)
    BK001413
    UniProtKB/TrEMBL
    Q6IMK1
    Related
    ENSRNOP00000074457.1, ENSRNOT00000081758.1
    Conserved Domains (3) summary
    COG5048
    Location:288355
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:278297
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
  2. NM_181374.2NP_852039.2  transcription factor Sp7 isoform 2

    See identical proteins and their annotated locations for NP_852039.2

    Status: PROVISIONAL

    Source sequence(s)
    BK001412
    UniProtKB/TrEMBL
    Q6IMK2
    Related
    ENSRNOP00000018828.2, ENSRNOT00000018828.3
    Conserved Domains (3) summary
    COG5048
    Location:306373
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:296315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:337362
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    143957316..143967488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594791.1XP_017450280.1  transcription factor Sp7 isoform X1

    UniProtKB/TrEMBL
    Q6IMK2
    Conserved Domains (3) summary
    COG5048
    Location:306373
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:296315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:337362
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017594792.1XP_017450281.1  transcription factor Sp7 isoform X2

    UniProtKB/TrEMBL
    Q6IMK1
    Conserved Domains (3) summary
    COG5048
    Location:288355
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:278297
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
  3. XM_008765706.2XP_008763928.1  transcription factor Sp7 isoform X1

    See identical proteins and their annotated locations for XP_008763928.1

    UniProtKB/TrEMBL
    Q6IMK2
    Conserved Domains (3) summary
    COG5048
    Location:306373
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:296315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:337362
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006242390.3XP_006242452.1  transcription factor Sp7 isoform X2

    See identical proteins and their annotated locations for XP_006242452.1

    UniProtKB/TrEMBL
    Q6IMK1
    Conserved Domains (3) summary
    COG5048
    Location:288355
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:278297
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    129919226..129927844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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