Sp7 Sp7 transcription factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sp7provided by RGD
Official Full Name: Sp7 transcription factorprovided by RGD
Primary source: RGD:631377
See related: Ensembl:ENSRNOG00000014082 AllianceGenome:RGD:631377
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Osx
Summary: Predicted to enable DEAD/H-box RNA helicase binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in hematopoietic stem cell differentiation; positive regulation of stem cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within osteoblast differentiation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 5.1), Uterus (RPKM 0.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (133484609..133494788, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (143957316..143967488, complement)

Chromosome 7 - NC_051342.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spatio-temporal immunolocalization of VEGF-A, Runx2, and osterix during the early steps of intramembranous ossification of the alveolar process in rat embryos.
Title: Spatio-temporal immunolocalization of VEGF-A, Runx2, and osterix during the early steps of intramembranous ossification of the alveolar process in rat embryos.
Expression of RUNX2 and Osterix in Rat Mesenchymal Stem Cells during Culturing in Osteogenic-Conditioned Medium.
Title: Expression of RUNX2 and Osterix in Rat Mesenchymal Stem Cells during Culturing in Osteogenic-Conditioned Medium.
BMP2-mimicking peptide modified with E7 coupling to calcined bovine bone enhanced bone regeneration associating with activation of the Runx2/SP7 signaling axis.
Title: BMP2-mimicking peptide modified with E7 coupling to calcined bovine bone enhanced bone regeneration associating with activation of the Runx2/SP7 signaling axis.
Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation via Regulating the Binding Ability of H3K9me3 with the Promoters of Runx2, Osterix and Osteocalcin.
Title: Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation via Regulating the Binding Ability of H3K9me3 with the Promoters of Runx2, Osterix and Osteocalcin.
the results indicate that, Osx-overexpression promotes ADSCs' osteogenesis both in vitro and in vivo, which could be enhanced by release of VEGF.
Title: In Situ Release of VEGF Enhances Osteogenesis in 3D Porous Scaffolds Engineered with Osterix-Modified Adipose-Derived Stem Cells.
In orthodontic tooth movement, the expression of RUNX2 and OSX was upregulated as a result of external stimulation, suggesting that the two genes is involved in periodontal tissue remodeling and plays an important role in periodontal tissue remodeling.
Title: Expression and function of osteogenic genes runt-related transcription factor 2 and osterix in orthodontic tooth movement in rats.
positive expression for Osterix and HNK1 in undifferentiated ectomesenchymal cells in early and late stages; Sox10 was present only in early stages in undifferentiated cells
Title: Temporo-spatial analysis of Osterix, HNK1 and Sox10 during odontogenesis and maxillaries osteogenesis.
VDR may mediate the increased expression levels of BMP2, Runx2 and Osterix by positively regulating calcium levels in primary primary renal tubular epithelial cells.
Title: Role of calcium in the regulation of bone morphogenetic protein 2, runt-related transcription factor 2 and Osterix in primary renal tubular epithelial cells by the vitamin D receptor.
results suggest that SUMOylation might regulate the transcriptional activity of Osterix in odontoblast lineage cells, and thus play important roles in odontoblast differentiation and regeneration
Title: Localization of SUMOylation factors and Osterix in odontoblast lineage cells during dentin formation and regeneration.
Glucocorticoids may induce femoral head osteonecrosis by down-regulating Runx2/Osterix (Osx) mRNA and up-regulating AJ18 mRNA.
Title: Dynamic expression of Runx2, Osterix and AJ18 in the femoral head of steroid-induced osteonecrosis in rats.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

PMC151001P1 (e-PCR)
- UniSTS:271129

d7mit1 (e-PCR)
- UniSTS:122293

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DEAD/H-box RNA helicase binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to zinc ion starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cementum mineralization	ISO Inferred from Sequence Orthology more info
involved_in diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor Sp7

Names: osterix

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037632.1 → NP_001032721.1 transcription factor Sp7 isoform 1

See identical proteins and their annotated locations for NP_001032721.1

Status: PROVISIONAL

Source sequence(s)

BK001413

UniProtKB/TrEMBL

Q6IMK1

Related

ENSRNOP00000074457.1, ENSRNOT00000081758.2

Conserved Domains (3) summary

COG5048
Location:288 → 355

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:278 → 297

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:319 → 344

zf-H2C2_2; Zinc-finger double domain
NM_181374.2 → NP_852039.2 transcription factor Sp7 isoform 2

See identical proteins and their annotated locations for NP_852039.2

Status: PROVISIONAL

Source sequence(s)

BK001412

UniProtKB/TrEMBL

Q6IMK2

Related

ENSRNOP00000018828.2, ENSRNOT00000018828.4

Conserved Domains (3) summary

COG5048
Location:306 → 373

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:296 → 315

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:337 → 362

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

NC_051342.1 Reference mRatBN7.2 Primary Assembly

Range

133484609..133494788 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594791.2 → XP_017450280.1 transcription factor Sp7 isoform X1

UniProtKB/TrEMBL

Q6IMK2

Conserved Domains (3) summary

COG5048
Location:306 → 373

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:296 → 315

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:337 → 362

zf-H2C2_2; Zinc-finger double domain