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Kansl2 KAT8 regulatory NSL complex subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300206, updated on 30-Jul-2025
Symbol
Kansl2provided by RGD
Full Name
KAT8 regulatory NSL complex subunit 2provided by RGD
Primary source
RGD:1303127
See related
Ensembl:ENSRNOG00000060185 AllianceGenome:RGD:1303127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1303127
Summary
Predicted to be involved in chromatin organization. Predicted to be located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Predicted to be part of NSL complex. Predicted to be active in mitochondrion. Orthologous to human KANSL2 (KAT8 regulatory NSL complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Heart (RPKM 244.7), Thymus (RPKM 192.7) and 9 other tissues See more
Orthologs
human mouse all
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See Kansl2 in Genome Data Viewer
Location:
7q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131548062..131564876, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129669031..129685750, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140196943..140213686, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene lactalbumin, alpha Neighboring gene olfactory receptor family 11 subfamily M member 3 Neighboring gene small nucleolar RNA, H/ACA box 34 Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene cyclin T1 Neighboring gene sperm microtubule inner protein 11

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Cai Y, et al. J Biol Chem, 2010 Feb 12. PMID 20018852, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC94200

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NSL complex IEA
Inferred from Electronic Annotation
more info
  
part_of NSL complex ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
KAT8 regulatory NSL complex subunit 2
Names
NSL complex protein NSL2
non-specific lethal 2 homolog
uncharacterized protein C12orf41 homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004244.3 → NP_001004244.2  KAT8 regulatory NSL complex subunit 2

    See identical proteins and their annotated locations for NP_001004244.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    G3V7H0, Q6AY70
    UniProtKB/TrEMBL
    A0A0G2K3M8
    Conserved Domains (1) summary
    pfam13891
    Location:28 → 92
    zf-C3Hc3H; Potential DNA-binding domain

  2. NM_001421308.1 → NP_001408237.1  KAT8 regulatory NSL complex subunit 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    G3V7H0, Q6AY70
    UniProtKB/TrEMBL
    A0A0G2K3M8
    Related
    ENSRNOP00000073779.2, ENSRNOT00000086886.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    131548062..131564876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765693.4 → XP_008763915.1  KAT8 regulatory NSL complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_008763915.1

    UniProtKB/Swiss-Prot
    G3V7H0, Q6AY70
    UniProtKB/TrEMBL
    A0A0G2K3M8
    Conserved Domains (1) summary
    pfam13891
    Location:28 → 92
    zf-C3Hc3H; Potential DNA-binding domain

  2. XM_063263374.1 → XP_063119444.1  KAT8 regulatory NSL complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K3Q1

  3. XM_063263375.1 → XP_063119445.1  KAT8 regulatory NSL complex subunit 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY70.2 GenPept UniProtKB/Swiss-Prot:Q6AY70

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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