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SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 [ Homo sapiens (human) ]

Gene ID: 30014, updated on 9-Aug-2021

Summary

Official Symbol
SPANXA1provided by HGNC
Official Full Name
sperm protein associated with the nucleus, X-linked, family member A1provided by HGNC
Primary source
HGNC:HGNC:11218
See related
Ensembl:ENSG00000198021 MIM:300305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAP-X; SPANX; CT11.1; CT11.3; SPAN-X; SPAN-Xa; SPAN-Xb; SPANX-A
Summary
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 14.3) See more
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Genomic context

See SPANXA1 in Genome Data Viewer
Location:
Xq27.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (141583674..141584738, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (140671796..140672860, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RBMX2 pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 5 Neighboring gene SPANXA2 overlapping transcript 1 Neighboring gene SPANX family member A2 Neighboring gene uncharacterized LOC645188

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC61861

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
sperm protein associated with the nucleus on the X chromosome A
Names
Cancer/testis antigen 11.3
Cancer/testis-associated protein CTp11
Nuclear-associated protein SPAN-Xc
SPANX family member A
SPANX family, member A1
Sperm protein associated with the nucleus on the X chromosome C
cancer/testis antigen 11.1
cancer/testis antigen family 11, member 1
nuclear-associated protein SPAN-Xa
sperm protein associated with the nucleus, X chromosome, family member A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013453.3NP_038481.2  sperm protein associated with the nucleus on the X chromosome A

    See identical proteins and their annotated locations for NP_038481.2

    Status: REVIEWED

    Source sequence(s)
    AF098306, AI208372, CB115288
    Consensus CDS
    CCDS14674.1
    UniProtKB/Swiss-Prot
    Q9NS26
    Related
    ENSP00000359550.3, ENST00000370519.3
    Conserved Domains (1) summary
    pfam07458
    Location:281
    SPAN-X; Sperm protein associated with nucleus, mapped to X chromosome

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    141583674..141584738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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