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Pkdrej polycystin family receptor for egg jelly [ Rattus norvegicus (Norway rat) ]

Gene ID: 300124, updated on 17-Aug-2024

Summary

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Official Symbol
Pkdrejprovided by RGD
Official Full Name
polycystin family receptor for egg jellyprovided by RGD
Primary source
RGD:1306587
See related
EnsemblRapid:ENSRNOG00000029591 AllianceGenome:RGD:1306587
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to act upstream of or within regulation of acrosome reaction. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human PKDREJ (polycystin family receptor for egg jelly). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See Pkdrej in Genome Data Viewer
Location:
7q34
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (118788939..118795313, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (116909094..116915468, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (126695498..126701872, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene microRNA let-7b Neighboring gene peroxisome proliferator activated receptor alpha Neighboring gene cysteine rich, DPF motif domain containing 1 Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene G-2 and S-phase expressed 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A polycystin-1 controls postcopulatory reproductive selection in mice. Sutton KA, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18562295, Free PMC Article
  2. Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head. Butscheid Y, et al. Mol Reprod Dev, 2006 Mar. PMID 16261614
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of acrosome reaction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polycystin family receptor for egg jelly
Names
polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
polycystic kidney disease and receptor for egg jelly-related protein
polycystin (PKD) family receptor for egg jelly

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134866.1 → NP_001128338.1  polycystin family receptor for egg jelly precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HTF2, D3ZCW6
    Related
    ENSRNOP00000048039.2, ENSRNOT00000041057.5
    Conserved Domains (3) summary
    cd01752
    Location:1111 → 1226
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam02010
    Location:132 → 598
    REJ; REJ domain
    pfam08016
    Location:1616 → 2046
    PKD_channel; Polycystin cation channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    118788939..118795313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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