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NXPH1 neurexophilin 1 [ Homo sapiens (human) ]

Gene ID: 30010, updated on 17-Jun-2024


Official Symbol
NXPH1provided by HGNC
Official Full Name
neurexophilin 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000122584 MIM:604639; AllianceGenome:HGNC:20693
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPH1; Nbla00697
This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. [provided by RefSeq, Jul 2008]
Biased expression in adrenal (RPKM 15.5) and brain (RPKM 12.8) See more
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Genomic context

See NXPH1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (8433609..8752961)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (8554700..8873809)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (8473239..8792591)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901587 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:8254569-8255768 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:8261122-8261678 Neighboring gene islet cell autoantigen 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:8342998-8343560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:8343561-8344122 Neighboring gene ICA1 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:8391097-8391728 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:8391729-8392358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:8473803-8474350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:8474351-8474898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:8474899-8475446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:8480847-8481347 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:8482526-8482705 Neighboring gene uncharacterized LOC105375144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:8783491-8783991 Neighboring gene Sharpr-MPRA regulatory region 4649 Neighboring gene MPRA-validated peak6368 silencer Neighboring gene ribosomal protein L9 pseudogene 19 Neighboring gene VISTA enhancer hs799 Neighboring gene Sharpr-MPRA regulatory region 911 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:9393157-9393764 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:9394915-9395416 Neighboring gene NANOG hESC enhancer GRCh37_chr7:9497177-9497869 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 68

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
EBI GWAS Catalog
Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.
EBI GWAS Catalog
Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152745.3NP_689958.1  neurexophilin-1 precursor

    See identical proteins and their annotated locations for NP_689958.1

    Status: REVIEWED

    Source sequence(s)
    AA575925, AB047362, AC004613, AC004861, BX107562
    Consensus CDS
    P58417, Q8NB31
    B2RCJ3, Q3LID8
    ENSP00000384551.1, ENST00000405863.6
    Conserved Domains (1) summary

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060931.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)