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FSCN3 fascin actin-bundling protein 3 [ Homo sapiens (human) ]

Gene ID: 29999, updated on 1-Jun-2020

Summary

Official Symbol
FSCN3provided by HGNC
Official Full Name
fascin actin-bundling protein 3provided by HGNC
Primary source
HGNC:HGNC:3961
See related
Ensembl:ENSG00000106328 MIM:615800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 43.5) See more
Orthologs

Genomic context

See FSCN3 in Genome Data Viewer
Location:
7q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (127593736..127602144)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127233689..127241851)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375489 Neighboring gene PAX4 5' regulatory region Neighboring gene GRIP and coiled-coil domain containing 1 Neighboring gene ADP ribosylation factor 5 Neighboring gene paired box 4 Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene CD2 cytoplasmic tail binding protein 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ARF5

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding, bridging IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
cell projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
filopodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth cone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fascin-3
Names
fascin actin-bundling protein 3, testicular
fascin homolog 3, actin-bundling protein, testicular
testicular secretory protein Li 18
testis fascin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020369.3NP_065102.1  fascin-3

    See identical proteins and their annotated locations for NP_065102.1

    Status: VALIDATED

    Source sequence(s)
    AC073934, AF281049, BC035606
    Consensus CDS
    CCDS34746.1
    UniProtKB/Swiss-Prot
    Q9NQT6
    UniProtKB/TrEMBL
    A0A140VK18
    Related
    ENSP00000265825.5, ENST00000265825.6
    Conserved Domains (2) summary
    cd00257
    Location:386498
    Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
    pfam06268
    Location:271381
    Fascin; Fascin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    127593736..127602144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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