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BICRA BRD4 interacting chromatin remodeling complex associated protein [ Homo sapiens (human) ]

Gene ID: 29998, updated on 23-Sep-2022

Summary

Official Symbol
BICRAprovided by HGNC
Official Full Name
BRD4 interacting chromatin remodeling complex associated proteinprovided by HGNC
Primary source
HGNC:HGNC:4332
See related
Ensembl:ENSG00000063169 MIM:605690; AllianceGenome:HGNC:4332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSS12; GLTSCR1; SMARCK1
Summary
Enables transcription regulator activator activity. Involved in positive regulation of transcription, DNA-templated. Located in nucleus. Part of SWI/SNF complex. Implicated in Coffin-Siris syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 1.9), prostate (RPKM 1.7) and 25 other tissues See more
Orthologs
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Genomic context

See BICRA in Genome Data Viewer
Location:
19q13.33
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47608196..47703277)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (50439021..50534101)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48111453..48206534)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 541 Neighboring gene RNA, 7SL, cytoplasmic 322, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9389 Neighboring gene uncharacterized LOC124904733 Neighboring gene EH domain containing 2 Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene NOP53 ribosome biogenesis factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Coffin-Siris syndrome 12
MedGen: C5444111 OMIM: 619325 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
BRD4-interacting chromatin-remodeling complex-associated protein
Names
BRD4 interacting chromatin remodelling complex associated protein
glioma tumor suppressor candidate region gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394372.1NP_001381301.1  BRD4-interacting chromatin-remodeling complex-associated protein

    Status: VALIDATED

    Source sequence(s)
    AC008985, AC010331, AC010519
    UniProtKB/Swiss-Prot
    A8MW01
    Related
    ENSP00000469738.2, ENST00000594866.3
    Conserved Domains (2) summary
    PHA03247
    Location:314792
    PHA03247; large tegument protein UL36; Provisional
    pfam15249
    Location:10911192
    GLTSCR1; Conserved region of unknown function on GLTSCR protein
  2. NM_015711.3NP_056526.3  BRD4-interacting chromatin-remodeling complex-associated protein

    See identical proteins and their annotated locations for NP_056526.3

    Status: VALIDATED

    Source sequence(s)
    AA961479, AA994408, AF182077, BC032065, BX362862
    Consensus CDS
    CCDS46134.1
    UniProtKB/Swiss-Prot
    A8MW01, Q9NZM4
    Related
    ENSP00000379946.2, ENST00000396720.7
    Conserved Domains (2) summary
    PHA03247
    Location:314792
    PHA03247; large tegument protein UL36; Provisional
    pfam15249
    Location:10911192
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    47608196..47703277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    50439021..50534101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)