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PACSIN1 protein kinase C and casein kinase substrate in neurons 1 [ Homo sapiens (human) ]

Gene ID: 29993, updated on 17-Feb-2019

Summary

Official Symbol
PACSIN1provided by HGNC
Official Full Name
protein kinase C and casein kinase substrate in neurons 1provided by HGNC
Primary source
HGNC:HGNC:8570
See related
Ensembl:ENSG00000124507 MIM:606512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDPI
Expression
Biased expression in brain (RPKM 42.1) and lymph node (RPKM 1.5) See more
Orthologs

Genomic context

See PACSIN1 in Genome Data Viewer
Location:
6p21.31
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (34466061..34536262)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (34433838..34503000)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RPS10-NUDT3 readthrough Neighboring gene nudix hydrolase 3 Neighboring gene ribosomal protein S10 Neighboring gene SAM pointed domain containing ETS transcription factor Neighboring gene interferon induced transmembrane protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1379

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein kinase C and casein kinase substrate in neurons protein 1
Names
syndapin I
syndapin-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199583.2NP_001186512.1  protein kinase C and casein kinase substrate in neurons protein 1

    See identical proteins and their annotated locations for NP_001186512.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon and encodes the same protein as variant 1.
    Source sequence(s)
    AL157372, BC040228, BP251080
    Consensus CDS
    CCDS4793.1
    UniProtKB/Swiss-Prot
    Q9BY11
    UniProtKB/TrEMBL
    Q5TZC3
    Related
    ENSP00000439639.1, ENST00000538621.2
    Conserved Domains (2) summary
    cd07680
    Location:19276
    F-BAR_PACSIN1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)
    cd11998
    Location:388443
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
  2. NM_020804.5NP_065855.1  protein kinase C and casein kinase substrate in neurons protein 1

    See identical proteins and their annotated locations for NP_065855.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL157372, AL834211, BP211882
    Consensus CDS
    CCDS4793.1
    UniProtKB/Swiss-Prot
    Q9BY11
    UniProtKB/TrEMBL
    Q5TZC3
    Related
    ENSP00000484060.1, ENST00000620693.4
    Conserved Domains (2) summary
    cd07680
    Location:19276
    F-BAR_PACSIN1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)
    cd11998
    Location:388443
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    34466061..34536262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514541.1XP_011512843.1  protein kinase C and casein kinase substrate in neurons protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011512843.1

    UniProtKB/Swiss-Prot
    Q9BY11
    UniProtKB/TrEMBL
    Q5TZC3
    Conserved Domains (2) summary
    cd07680
    Location:19276
    F-BAR_PACSIN1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1)
    cd11998
    Location:388443
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
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