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OBP2A odorant binding protein 2A [ Homo sapiens (human) ]

Gene ID: 29991, updated on 22-Jan-2023

Summary

Official Symbol
OBP2Aprovided by HGNC
Official Full Name
odorant binding protein 2Aprovided by HGNC
Primary source
HGNC:HGNC:23380
See related
Ensembl:ENSG00000122136 MIM:164320; AllianceGenome:HGNC:23380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBP; LCN13; OBP2C; OBPIIa; hOBPIIa
Summary
This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 2.5), skin (RPKM 0.2) and 1 other tissue See more
Orthologs
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Genomic context

See OBP2A in Genome Data Viewer
Location:
9q34.3
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (135546126..135549969)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (147774075..147777763)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (138437972..138441815)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928525 Neighboring gene mitochondrial ribosomal protein S2 Neighboring gene lipocalin 1 Neighboring gene uncharacterized LOC107987040 Neighboring gene progestagen associated endometrial protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables odorant binding NAS
Non-traceable Author Statement
more info
PubMed 
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of chemical stimulus TAS
Traceable Author Statement
more info
PubMed 
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
odorant-binding protein 2a
Names
odorant-binding protein IIa
putative odorant-binding protein 2c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029693.1 RefSeqGene

    Range
    4988..8831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001293189.2NP_001280118.1  odorant-binding protein 2a isoform gamma precursor

    Status: REVIEWED

    Source sequence(s)
    AI219510, AJ251024, AL161452, BC143803
    Consensus CDS
    CCDS78455.1
    UniProtKB/Swiss-Prot
    Q9NY56
    UniProtKB/TrEMBL
    B7ZLH4, Q5T8A5
    Related
    ENSP00000342097.3, ENST00000340780.7
    Conserved Domains (1) summary
    pfam00061
    Location:26130
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  2. NM_001293193.2NP_001280122.1  odorant-binding protein 2a isoform delta precursor

    Status: REVIEWED

    Source sequence(s)
    AI219510, AJ251023, AL161452, BC069563
    Consensus CDS
    CCDS78456.1
    UniProtKB/Swiss-Prot
    Q9NY56
    UniProtKB/TrEMBL
    Q5T8A4
    Related
    ENSP00000340950.4, ENST00000342114.8
    Conserved Domains (1) summary
    pfam00061
    Location:107141
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  3. NM_001412135.1NP_001399064.1  odorant-binding protein 2a isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    CP068269
    UniProtKB/TrEMBL
    B7ZLH4
  4. NM_014582.3NP_055397.1  odorant-binding protein 2a isoform alpha precursor

    See identical proteins and their annotated locations for NP_055397.1

    Status: REVIEWED

    Source sequence(s)
    AI219510, AJ251021, AL161452
    Consensus CDS
    CCDS6992.1
    UniProtKB/Swiss-Prot
    Q9NY55, Q9NY56
    Related
    ENSP00000360841.1, ENST00000371776.6
    Conserved Domains (1) summary
    pfam00061
    Location:26164
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RNA

  1. NR_120603.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI219510, AJ251022, AJ251023, AL161452
    Related
    ENST00000471886.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    135546126..135549969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    147774075..147777763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)