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Cyrib CYFIP related Rac1 interactor B [ Rattus norvegicus (Norway rat) ]

Gene ID: 299909, updated on 3-Apr-2024

Summary

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Official Symbol
Cyribprovided by RGD
Official Full Name
CYFIP related Rac1 interactor Bprovided by RGD
Primary source
RGD:1307697
See related
Ensembl:ENSRNOG00000061246 AllianceGenome:RGD:1307697
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam49b; RGD1307697
Summary
Predicted to enable MHC class Ib protein binding, via antigen binding activity groove and small GTPase binding activity. Predicted to be involved in several processes, including positive regulation of interferon-gamma production; positive regulation of memory T cell activation; and regulation of organelle organization. Predicted to be located in cilium and mitochondrion. Orthologous to human CYRIB (CYFIP related Rac1 interactor B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 220.8), Thymus (RPKM 208.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cyrib in Genome Data Viewer
Location:
7q33
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (97524941..97649846, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (95633876..95760588, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (104514566..104641875, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC120093676 Neighboring gene gasdermin D like 1 Neighboring gene gasdermin C Neighboring gene uncharacterized LOC134479920 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Neighboring gene uncharacterized LOC134479921 Neighboring gene adenylate cyclase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Fort L, et al. Nat Cell Biol, 2018 Oct. PMID 30250061, Free PMC Article
  2. FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. Chattaragada MS, et al. Oncogene, 2018 Feb 8. PMID 29059164, Free PMC Article
  3. CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Yuki KE, et al. Nat Microbiol, 2019 Sep. PMID 31285585
  4. Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nagarajan NA, et al. Nat Immunol, 2012 Apr 22. PMID 22522492, Free PMC Article
  5. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MHC class Ib protein binding, via antigen binding groove ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of memory T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CYFIP-related Rac1 interactor B
Names
family with sequence similarity 49, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126267.2 → NP_001119739.1  CYFIP-related Rac1 interactor B

    See identical proteins and their annotated locations for NP_001119739.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166469
    UniProtKB/TrEMBL
    A0A0G2K4V6, B2GUZ9
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    97524941..97649846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078775.2 → XP_038934703.1  CYFIP-related Rac1 interactor B isoform X3

    Conserved Domains (1) summary
    pfam07159
    Location:1 → 174
    DUF1394; Protein of unknown function (DUF1394)

  2. XM_039078773.2 → XP_038934701.1  CYFIP-related Rac1 interactor B isoform X3

    Conserved Domains (1) summary
    pfam07159
    Location:1 → 174
    DUF1394; Protein of unknown function (DUF1394)

  3. XM_008765501.4 → XP_008763723.1  CYFIP-related Rac1 interactor B isoform X1

    See identical proteins and their annotated locations for XP_008763723.1

    UniProtKB/TrEMBL
    A0A0G2JXI6, A0A0G2K4V6, A6HRP7
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  4. XM_039078771.2 → XP_038934699.1  CYFIP-related Rac1 interactor B isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4V6, B2GUZ9
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  5. XM_017594751.3 → XP_017450240.1  CYFIP-related Rac1 interactor B isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4V6, B2GUZ9
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  6. XM_039078774.2 → XP_038934702.1  CYFIP-related Rac1 interactor B isoform X3

    Conserved Domains (1) summary
    pfam07159
    Location:1 → 174
    DUF1394; Protein of unknown function (DUF1394)

  7. XM_006241633.2 → XP_006241695.1  CYFIP-related Rac1 interactor B isoform X2

    See identical proteins and their annotated locations for XP_006241695.1

    UniProtKB/TrEMBL
    A0A0G2K4V6, B2GUZ9
    Related
    ENSRNOP00000073189.2
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  8. XM_006241635.5 → XP_006241697.1  CYFIP-related Rac1 interactor B isoform X1

    See identical proteins and their annotated locations for XP_006241697.1

    UniProtKB/TrEMBL
    A0A0G2JXI6, A0A0G2K4V6, A6HRP7
    Related
    ENSRNOP00000070286.2
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

  9. XM_063263248.1 → XP_063119318.1  CYFIP-related Rac1 interactor B isoform X2

    UniProtKB/TrEMBL
    B2GUZ9
Nucleotide Protein Strain
Heading Accession and Version

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