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SLC2A8 solute carrier family 2 member 8 [ Homo sapiens (human) ]

Gene ID: 29988, updated on 22-Aug-2020

Summary

Official Symbol
SLC2A8provided by HGNC
Official Full Name
solute carrier family 2 member 8provided by HGNC
Primary source
HGNC:HGNC:13812
See related
Ensembl:ENSG00000136856 MIM:605245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT8; GLUTX1
Summary
This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Expression
Broad expression in testis (RPKM 16.3), adrenal (RPKM 7.3) and 24 other tissues See more
Orthologs

Genomic context

See SLC2A8 in Genome Data Viewer
Location:
9q33.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (127397140..127407898)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130159417..130170177)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene uncharacterized LOC105376278 Neighboring gene GTPase activating Rap/RanGAP domain like 3 Neighboring gene density regulated re-initiation and release factor pseudogene Neighboring gene uncharacterized LOC112268056 Neighboring gene zinc finger protein 79 Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene ribosomal protein L12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dehydroascorbic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
fructose transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose binding IEA
Inferred from Electronic Annotation
more info
 
glucose transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
dehydroascorbic acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
fructose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
hexose transmembrane transport TAS
Traceable Author Statement
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
male meiosis I IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
clathrin-coated vesicle membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 8
Names
glucose transporter type 8
glucose transporter type X1
solute carrier family 2 (facilitated glucose transporter), member 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271711.2NP_001258640.1  solute carrier family 2, facilitated glucose transporter member 8 isoform 2

    See identical proteins and their annotated locations for NP_001258640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform 2 is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF289587, AI818661, AL445222, BC019043, HY025817
    Consensus CDS
    CCDS65138.1
    UniProtKB/Swiss-Prot
    Q9NY64
    UniProtKB/TrEMBL
    Q5VVV9, Q8WZ05
    Related
    ENSP00000362458.3, ENST00000373360.7
    Conserved Domains (1) summary
    cd06174
    Location:38331
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. NM_001271712.2NP_001258641.1  solute carrier family 2, facilitated glucose transporter member 8 isoform 3

    See identical proteins and their annotated locations for NP_001258641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI818661, BC019043, BX395379, HY025817
    Consensus CDS
    CCDS75903.1
    UniProtKB/Swiss-Prot
    Q9NY64
    UniProtKB/TrEMBL
    A0A087WT42
    Related
    ENSP00000477568.1, ENST00000610552.4
    Conserved Domains (1) summary
    cd06174
    Location:90296
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. NM_014580.5NP_055395.2  solute carrier family 2, facilitated glucose transporter member 8 isoform 1

    See identical proteins and their annotated locations for NP_055395.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform 1.
    Source sequence(s)
    AF289587, AL445222, BC019043, HY025817
    Consensus CDS
    CCDS6870.1
    UniProtKB/Swiss-Prot
    Q9NY64
    UniProtKB/TrEMBL
    A0A024R871, Q8WZ05
    Related
    ENSP00000362469.3, ENST00000373371.8
    Conserved Domains (2) summary
    cd06174
    Location:38459
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    PRK10077
    Location:36472
    xylE; D-xylose transporter XylE; Provisional

RNA

  1. NR_073416.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF289587, AL445222, BC019043, BM044230, HY025817

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    127397140..127407898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717084.3XP_006717147.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X2

    Conserved Domains (1) summary
    cd06174
    Location:38423
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. XM_011518602.2XP_011516904.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:38433
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    PRK10077
    Location:36446
    xylE; D-xylose transporter XylE; Provisional
  3. XM_024447526.1XP_024303294.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X5

    Related
    ENSP00000391213.1, ENST00000430147.1
    Conserved Domains (1) summary
    cl26863
    Location:1261
    Sugar_tr; Sugar (and other) transporter
  4. XM_017014653.1XP_016870142.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X6

    UniProtKB/TrEMBL
    Q8WZ05
    Conserved Domains (1) summary
    pfam00083
    Location:1187
    Sugar_tr; Sugar (and other) transporter
  5. XM_011518603.3XP_011516905.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X3

    Conserved Domains (1) summary
    cd06174
    Location:118324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  6. XM_011518604.3XP_011516906.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X4

    Conserved Domains (1) summary
    cd06174
    Location:8298
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RNA

  1. XR_929783.2 RNA Sequence

  2. XR_002956777.1 RNA Sequence

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