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SLC2A8 solute carrier family 2 member 8 [ Homo sapiens (human) ]

Gene ID: 29988, updated on 18-Sep-2024

Summary

Official Symbol
SLC2A8provided by HGNC
Official Full Name
solute carrier family 2 member 8provided by HGNC
Primary source
HGNC:HGNC:13812
See related
Ensembl:ENSG00000136856 MIM:605245; AllianceGenome:HGNC:13812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT8; GLUTX1
Summary
This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Expression
Broad expression in testis (RPKM 16.3), adrenal (RPKM 7.3) and 24 other tissues See more
Orthologs
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Genomic context

See SLC2A8 in Genome Data Viewer
Location:
9q33.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127397169..127407898)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139603648..139615379)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130159448..130170177)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene GTPase activating Rap/RanGAP domain like 3 Neighboring gene DENR pseudogene 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:130094714-130095913 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:130098321-130099520 Neighboring gene Sharpr-MPRA regulatory region 1510 Neighboring gene uncharacterized LOC124902275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130146967-130147700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130168662-130169228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130180180-130180827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130180828-130181474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:130185748-130186690 Neighboring gene zinc finger protein 79 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29040 Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene ribosomal protein L12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
 
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables D-glucose transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables D-glucose transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables dehydroascorbic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables fructose transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in D-glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in D-glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in dehydroascorbic acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fructose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in lysosomal membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 8
Names
glucose transporter type 8
glucose transporter type X1
solute carrier family 2 (facilitated glucose transporter), member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271711.2NP_001258640.1  solute carrier family 2, facilitated glucose transporter member 8 isoform 2

    See identical proteins and their annotated locations for NP_001258640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform 2 is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF289587, AI818661, AL445222, BC019043, HY025817
    Consensus CDS
    CCDS65138.1
    UniProtKB/TrEMBL
    Q5VVV9
    Related
    ENSP00000362458.3, ENST00000373360.7
    Conserved Domains (1) summary
    cd06174
    Location:38331
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. NM_001271712.2NP_001258641.1  solute carrier family 2, facilitated glucose transporter member 8 isoform 3

    See identical proteins and their annotated locations for NP_001258641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI818661, BC019043, BX395379, HY025817
    Consensus CDS
    CCDS75903.1
    UniProtKB/TrEMBL
    A0A087WT42, Q5VVV4
    Related
    ENSP00000477568.1, ENST00000610552.4
    Conserved Domains (1) summary
    cd06174
    Location:90296
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. NM_014580.5NP_055395.2  solute carrier family 2, facilitated glucose transporter member 8 isoform 1

    See identical proteins and their annotated locations for NP_055395.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform 1.
    Source sequence(s)
    AF289587, AL445222, BC019043, HY025817
    Consensus CDS
    CCDS6870.1
    UniProtKB/Swiss-Prot
    Q8WUZ9, Q9NSC4, Q9NY64
    Related
    ENSP00000362469.3, ENST00000373371.8
    Conserved Domains (2) summary
    cd06174
    Location:38459
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    PRK10077
    Location:36472
    xylE; D-xylose transporter XylE; Provisional

RNA

  1. NR_073416.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF289587, AL445222, BC019043, BM044230, HY025817

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    127397169..127407898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423283.1XP_047279239.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X1

  2. XM_047423287.1XP_047279243.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X4

  3. XM_047423285.1XP_047279241.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X2

  4. XM_011518602.3XP_011516904.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X5

    Conserved Domains (2) summary
    cd06174
    Location:38433
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    PRK10077
    Location:36446
    xylE; D-xylose transporter XylE; Provisional
  5. XM_017014653.2XP_016870142.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X14

    UniProtKB/TrEMBL
    Q5VVV3, Q8WZ05
    Conserved Domains (1) summary
    pfam00083
    Location:1187
    Sugar_tr; Sugar (and other) transporter
  6. XM_047423293.1XP_047279249.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X12

    UniProtKB/TrEMBL
    Q5VVV4
  7. XM_047423286.1XP_047279242.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X3

  8. XM_006717084.4XP_006717147.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X6

    Conserved Domains (1) summary
    cd06174
    Location:38423
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  9. XM_024447526.2XP_024303294.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X13

    UniProtKB/TrEMBL
    Q5VVV4
    Related
    ENSP00000391213.1, ENST00000430147.1
    Conserved Domains (1) summary
    cl26863
    Location:1261
    Sugar_tr; Sugar (and other) transporter
  10. XM_047423294.1XP_047279250.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X15

    UniProtKB/TrEMBL
    Q5VVV4
  11. XM_047423288.1XP_047279244.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X7

  12. XM_047423289.1XP_047279245.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X9

  13. XM_047423290.1XP_047279246.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X11

  14. XM_047423292.1XP_047279248.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X11

  15. XM_011518603.4XP_011516905.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X8

    UniProtKB/TrEMBL
    Q5VVV4
    Conserved Domains (1) summary
    cd06174
    Location:118324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  16. XM_011518604.4XP_011516906.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X10

    Conserved Domains (1) summary
    cd06174
    Location:8298
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    139603648..139615379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362834.1XP_054218809.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X1

  2. XM_054362837.1XP_054218812.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X4

  3. XM_054362835.1XP_054218810.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X2

  4. XM_054362838.1XP_054218813.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X5

  5. XM_054362848.1XP_054218823.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X14

    UniProtKB/TrEMBL
    Q5VVV3, Q8WZ05
  6. XM_054362846.1XP_054218821.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X12

    UniProtKB/TrEMBL
    Q5VVV4
  7. XM_054362836.1XP_054218811.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X3

  8. XM_054362839.1XP_054218814.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X6

  9. XM_054362847.1XP_054218822.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X13

    UniProtKB/TrEMBL
    Q5VVV4
  10. XM_054362849.1XP_054218824.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X15

    UniProtKB/TrEMBL
    Q5VVV4
  11. XM_054362840.1XP_054218815.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X7

  12. XM_054362842.1XP_054218817.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X9

  13. XM_054362844.1XP_054218819.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X11

  14. XM_054362845.1XP_054218820.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X11

  15. XM_054362841.1XP_054218816.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X8

    UniProtKB/TrEMBL
    Q5VVV4
  16. XM_054362843.1XP_054218818.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X10

RNA

  1. XR_008487994.1 RNA Sequence

  2. XR_008487995.1 RNA Sequence

  3. XR_008487997.1 RNA Sequence

  4. XR_008487998.1 RNA Sequence

  5. XR_008487999.1 RNA Sequence

  6. XR_008488000.1 RNA Sequence

  7. XR_008487996.1 RNA Sequence