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UBQLN2 ubiquilin 2 [ Homo sapiens (human) ]

Gene ID: 29978, updated on 3-Jun-2018
Official Symbol
UBQLN2provided by HGNC
Official Full Name
ubiquilin 2provided by HGNC
Primary source
HGNC:HGNC:12509
See related
Ensembl:ENSG00000188021 MIM:300264; Vega:OTTHUMG00000021669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSK2; ALS15; CHAP1; N4BP4; PLIC2; HRIHFB2157
Summary
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
Orthologs
See UBQLN2 in Genome Data Viewer
Location:
Xp11.21
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (56563593..56567010)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (56590025..56593443)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) pseudogene Neighboring gene Kruppel like factor 8 Neighboring gene ribosomal protein L23a pseudogene 83 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 1 Neighboring gene negative regulator of P-body association Neighboring gene spindlin family member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of ubiquilin 2 (UBQLN2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

  • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
  • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10167, FLJ56541

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
autophagosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
ubiquilin-2
Names
Nedd4 binding protein 4
protein linking IAP with cytoskeleton 2
ubiquitin-like product Chap1/Dsk2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016249.1 RefSeqGene

    Range
    5001..8418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_665

mRNA and Protein(s)

  1. NM_013444.3NP_038472.2  ubiquilin-2

    See identical proteins and their annotated locations for NP_038472.2

    Status: REVIEWED

    Source sequence(s)
    AF189009, AU310783, BC069237, BI602998
    Consensus CDS
    CCDS14374.1
    UniProtKB/Swiss-Prot
    Q9UHD9
    Related
    ENSP00000345195.5, OTTHUMP00000023408, ENST00000338222.6, OTTHUMT00000056891
    Conserved Domains (4) summary
    smart00727
    Location:382426
    STI1; Heat shock chaperonin-binding motif
    cd01808
    Location:33103
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    smart00213
    Location:33103
    UBQ; Ubiquitin homologues
    cd14399
    Location:581620
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    56563593..56567010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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