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Sirt6 sirtuin 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299638, updated on 9-Sep-2018

Summary

Official Symbol
Sirt6provided by RGD
Official Full Name
sirtuin 6provided by RGD
Primary source
RGD:1305216
See related
Ensembl:ENSRNOG00000006393
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Thymus (RPKM 55.9), Lung (RPKM 55.2) and 9 other tissues See more
Orthologs

Genomic context

See Sirt6 in Genome Data Viewer
Location:
7q11
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (10937622..10943048)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (11106748..11112174)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein LOC100125368 Neighboring gene ankyrin repeat domain 24 Neighboring gene uncharacterized LOC102551996 Neighboring gene transducin-like enhancer of split 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC114368

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
NAD(P)+-protein-arginine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity (H3-K9 specific) IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity (H3-K9 specific) ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
base-excision repair IEA
Inferred from Electronic Annotation
more info
 
base-excision repair ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
histone H3-K9 deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-K9 modification IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation blood vessel branching IEA
Inferred from Electronic Annotation
more info
 
positive regulation blood vessel branching ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chondrocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chromatin silencing at telomere IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chromatin silencing at telomere ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomeric heterochromatin assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomeric heterochromatin assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
post-embryonic cardiac muscle cell growth involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ADP-ribosylation IEA
Inferred from Electronic Annotation
more info
 
protein ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
protein destabilization IEA
Inferred from Electronic Annotation
more info
 
protein destabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 
regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear telomeric heterochromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear telomeric heterochromatin ISO
Inferred from Sequence Orthology
more info
 
NOT nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-6
Names
NAD-dependent deacetylase sirtuin-6
NP_001026819.1
XP_006240958.1
XP_008763314.1
XP_017450209.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031649.1NP_001026819.1  NAD-dependent protein deacetylase sirtuin-6

    See identical proteins and their annotated locations for NP_001026819.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098923
    UniProtKB/TrEMBL
    Q4FZY2
    Related
    ENSRNOP00000008758.3, ENSRNOT00000008758.5
    Conserved Domains (1) summary
    cd01410
    Location:45257
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    10937622..10943048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240896.2XP_006240958.1  NAD-dependent protein deacetylase sirtuin-6 isoform X1

    See identical proteins and their annotated locations for XP_006240958.1

    Conserved Domains (1) summary
    cd01410
    Location:37249
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
  2. XM_017594720.1XP_017450209.1  NAD-dependent protein deacetylase sirtuin-6 isoform X2

    Conserved Domains (1) summary
    cd01410
    Location:29241
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
  3. XM_008765092.2XP_008763314.1  NAD-dependent protein deacetylase sirtuin-6 isoform X1

    See identical proteins and their annotated locations for XP_008763314.1

    Conserved Domains (1) summary
    cd01410
    Location:37249
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    6273425..6278851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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