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Lmnb2 lamin B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299625, updated on 13-Apr-2024

Summary

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Official Symbol
Lmnb2provided by RGD
Official Full Name
lamin B2provided by RGD
Primary source
RGD:1563803
See related
Ensembl:ENSRNOG00000025742 AllianceGenome:RGD:1563803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563803
Summary
Predicted to enable identical protein binding activity. Predicted to be located in lamin filament and nuclear membrane. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 61.5), Testes (RPKM 36.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9443308..9459468)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8792628..8808665)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11657870..11676936)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 7 Neighboring gene transfer RNA proline (anticodon AGG) 48 Neighboring gene growth arrest and DNA-damage-inducible, beta Neighboring gene uncharacterized LOC134479806 Neighboring gene transmembrane serine protease 9 Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene uncharacterized LOC120093773

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear lamins are differentially expressed in retinal neurons of the adult rat retina. Wakabayashi T, et al. Histochem Cell Biol, 2011 Oct. PMID 21842415
  2. cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Furukawa K, et al. Chromosome Res, 1994 Mar. PMID 8032679
  3. Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope. Goodchild RE, et al. Neuron, 2005 Dec 22. PMID 16364897
  4. Samp1 is a component of TAN lines and is required for nuclear movement. Borrego-Pinto J, et al. J Cell Sci, 2012 Mar 1. PMID 22349700
  5. A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Kim CE, et al. Proc Natl Acad Sci U S A, 2010 May 25. PMID 20457914, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear pore localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in lamin filament ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear lamina IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear lamina ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lamin-B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305235.1 → NP_001292164.1  lamin-B2

    See identical proteins and their annotated locations for NP_001292164.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I5ZMS1, D3ZLC1
    Related
    ENSRNOP00000022336.6, ENSRNOT00000022336.9
    Conserved Domains (2) summary
    pfam00038
    Location:41 → 397
    Filament; Intermediate filament protein
    pfam00932
    Location:463 → 570
    LTD; Lamin Tail Domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9443308..9459468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263176.1 → XP_063119246.1  lamin-B2 isoform X2

  2. XM_006241035.5 → XP_006241097.1  lamin-B2 isoform X1

    See identical proteins and their annotated locations for XP_006241097.1

    UniProtKB/TrEMBL
    A0A8I5ZPN1
    Related
    ENSRNOP00000080459.1
    Conserved Domains (3) summary
    pfam00932
    Location:429 → 536
    LTD; Lamin Tail Domain
    pfam15369
    Location:262 → 369
    KIAA1328; uncharacterized protein KIAA1328
    cl21478
    Location:205 → 298
    ATP-synt_B; ATP synthase B/B' CF(0)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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