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Lmnb2 lamin B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299625, updated on 5-Aug-2018

Summary

Official Symbol
Lmnb2provided by RGD
Official Full Name
lamin B2provided by RGD
Primary source
RGD:1563803
See related
Ensembl:ENSRNOG00000025742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563803
Expression
Biased expression in Thymus (RPKM 61.5), Testes (RPKM 36.1) and 9 other tissues See more
Orthologs

Genomic context

See Lmnb2 in Genome Data Viewer
Location:
7q11
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11657870..11676936)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (11828299..11844456)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553301 Neighboring gene G protein subunit gamma 7 Neighboring gene growth arrest and DNA-damage-inducible, beta Neighboring gene transmembrane serine protease 9 Neighboring gene translocase of inner mitochondrial membrane 13

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
    FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
lamin filament IEA
Inferred from Electronic Annotation
more info
 
lamin filament ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305235.1NP_001292164.1  lamin-B2

    See identical proteins and their annotated locations for NP_001292164.1

    Status: VALIDATED

    Source sequence(s)
    AC103000
    UniProtKB/TrEMBL
    D3ZLC1
    Related
    ENSRNOP00000022336.6, ENSRNOT00000022336.8
    Conserved Domains (2) summary
    pfam00038
    Location:41397
    Filament; Intermediate filament protein
    pfam00932
    Location:463570
    LTD; Lamin Tail Domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    11657870..11676936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765148.2XP_008763370.1  lamin-B2 isoform X1

    See identical proteins and their annotated locations for XP_008763370.1

    UniProtKB/TrEMBL
    D3ZLC1
    Conserved Domains (2) summary
    pfam00038
    Location:41397
    Filament; Intermediate filament protein
    pfam00932
    Location:463570
    LTD; Lamin Tail Domain
  2. XM_008765149.2XP_008763371.1  lamin-B2 isoform X1

    See identical proteins and their annotated locations for XP_008763371.1

    UniProtKB/TrEMBL
    D3ZLC1
    Conserved Domains (2) summary
    pfam00038
    Location:41397
    Filament; Intermediate filament protein
    pfam00932
    Location:463570
    LTD; Lamin Tail Domain
  3. XM_006241035.3XP_006241097.1  lamin-B2 isoform X2

    See identical proteins and their annotated locations for XP_006241097.1

    Conserved Domains (3) summary
    pfam00932
    Location:429536
    LTD; Lamin Tail Domain
    pfam15369
    Location:262369
    KIAA1328; uncharacterized protein KIAA1328
    cl21478
    Location:205298
    ATP-synt_B; ATP synthase B/B' CF(0)

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    6976982..6993012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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