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GYPE glycophorin E (MNS blood group) [ Homo sapiens (human) ]

Gene ID: 2996, updated on 23-Nov-2021

Summary

Official Symbol
GYPEprovided by HGNC
Official Full Name
glycophorin E (MNS blood group)provided by HGNC
Primary source
HGNC:HGNC:4705
See related
Ensembl:ENSG00000197465 MIM:138590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPE; MNS; GYPA; MiIX
Summary
The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 2.0), lung (RPKM 1.5) and 25 other tissues See more
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Genomic context

See GYPE in Genome Data Viewer
Location:
4q31.21
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (143870864..143912131, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (144792017..144826712, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ethanolamine kinase 1 pseudogene Neighboring gene uncharacterized LOC105377458 Neighboring gene uncharacterized LOC105377459 Neighboring gene salvador family WW domain containing protein 1 pseudogene Neighboring gene uncharacterized LOC101927636 Neighboring gene glycophorin B (MNS blood group)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
glycophorin-E
Names
glycophorin A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009173.1 RefSeqGene

    Range
    5005..39700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002102.4NP_002093.2  glycophorin-E precursor

    See identical proteins and their annotated locations for NP_002093.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC017864, BG528203, BX091225, M29610
    Consensus CDS
    CCDS47138.1
    UniProtKB/Swiss-Prot
    P15421
    Related
    ENSP00000400698.2, ENST00000437468.2
    Conserved Domains (1) summary
    pfam01102
    Location:5578
    Glycophorin_A; Glycophorin A
  2. NM_198682.3NP_941391.2  glycophorin-E precursor

    See identical proteins and their annotated locations for NP_941391.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC109812, BC017864, BC064396
    Consensus CDS
    CCDS47138.1
    UniProtKB/Swiss-Prot
    P15421
    Related
    ENSP00000351430.4, ENST00000358615.9
    Conserved Domains (1) summary
    pfam01102
    Location:5578
    Glycophorin_A; Glycophorin A

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    143870864..143912131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008139.2XP_016863628.1  glycophorin-E isoform X1

    UniProtKB/Swiss-Prot
    P15421
    Conserved Domains (1) summary
    pfam01102
    Location:5578
    Glycophorin_A; Glycophorin A
  2. XM_017008140.2XP_016863629.1  glycophorin-E isoform X1

    UniProtKB/Swiss-Prot
    P15421
    Conserved Domains (1) summary
    pfam01102
    Location:5578
    Glycophorin_A; Glycophorin A
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