Format

Send to:

Choose Destination

NRBP1 nuclear receptor binding protein 1 [ Homo sapiens (human) ]

Gene ID: 29959, updated on 11-Sep-2019

Summary

Official Symbol
NRBP1provided by HGNC
Official Full Name
nuclear receptor binding protein 1provided by HGNC
Primary source
HGNC:HGNC:7993
See related
Ensembl:ENSG00000115216 MIM:606010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MADM; NRBP; BCON3; MUDPNP
Expression
Ubiquitous expression in esophagus (RPKM 41.1), testis (RPKM 38.5) and 25 other tissues See more
Orthologs

Genomic context

See NRBP1 in Genome Data Viewer
Location:
2p23.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27427790..27442259)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27651473..27665126)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1G Neighboring gene ferritin heavy chain 1 pseudogene 3 Neighboring gene keratinocyte associated protein 3 Neighboring gene intraflagellar transport 172 Neighboring gene RNA, U6 small nuclear 986, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nuclear receptor binding protein 1 (NRBP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with NRBP1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
    Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27109, FLJ35541

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nuclear receptor-binding protein
Names
multiple domain putative nuclear protein
myeloid leukemia factor 1 adaptor molecule

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321357.1NP_001308286.1  nuclear receptor-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074117, AK122664, BC001221
    Consensus CDS
    CCDS1753.1
    UniProtKB/Swiss-Prot
    Q9UHY1
    Related
    ENSP00000233557.3, ENST00000233557.7
    Conserved Domains (1) summary
    cd14034
    Location:60334
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
  2. NM_001321358.2NP_001308287.1  nuclear receptor-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    Consensus CDS
    CCDS82433.1
    UniProtKB/Swiss-Prot
    Q9UHY1
    UniProtKB/TrEMBL
    F8W6G1
    Conserved Domains (1) summary
    cd14034
    Location:60342
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
  3. NM_001321359.2NP_001308288.1  nuclear receptor-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    Consensus CDS
    CCDS82433.1
    UniProtKB/Swiss-Prot
    Q9UHY1
    UniProtKB/TrEMBL
    F8W6G1
    Related
    ENSP00000369192.3, ENST00000379863.7
    Conserved Domains (1) summary
    cd14034
    Location:60342
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
  4. NM_001321361.2NP_001308290.1  nuclear receptor-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    UniProtKB/Swiss-Prot
    Q9UHY1
    Conserved Domains (2) summary
    smart00220
    Location:83332
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14034
    Location:60341
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
  5. NM_001321362.2NP_001308291.1  nuclear receptor-binding protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    UniProtKB/Swiss-Prot
    Q9UHY1
    Conserved Domains (1) summary
    cd14034
    Location:60333
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
  6. NM_001321363.2NP_001308292.1  nuclear receptor-binding protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    UniProtKB/Swiss-Prot
    Q9UHY1
    Conserved Domains (1) summary
    cl21453
    Location:60302
    PKc_like; Protein Kinases, catalytic domain
  7. NM_013392.4NP_037524.1  nuclear receptor-binding protein isoform 1

    See identical proteins and their annotated locations for NP_037524.1

    Status: VALIDATED

    Source sequence(s)
    BC001221, BQ949042
    Consensus CDS
    CCDS1753.1
    UniProtKB/Swiss-Prot
    Q9UHY1
    Related
    ENSP00000369181.3, ENST00000379852.8
    Conserved Domains (1) summary
    cd14034
    Location:60334
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27427790..27442259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center