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NRBP1 nuclear receptor binding protein 1 [ Homo sapiens (human) ]

Gene ID: 29959, updated on 7-Jan-2024

Summary

Official Symbol
NRBP1provided by HGNC
Official Full Name
nuclear receptor binding protein 1provided by HGNC
Primary source
HGNC:HGNC:7993
See related
Ensembl:ENSG00000115216 MIM:606010; AllianceGenome:HGNC:7993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MADM; NRBP; BCON3; MUDPNP
Summary
Predicted to enable protein homodimerization activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 41.1), testis (RPKM 38.5) and 25 other tissues See more
Orthologs
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Genomic context

See NRBP1 in Genome Data Viewer
Location:
2p23.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27427790..27442259)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27470161..27484612)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27650657..27665126)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27601343-27602213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11297 Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1G Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27618171-27618672 Neighboring gene ferritin heavy chain 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27665383-27665925 Neighboring gene keratinocyte associated protein 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27676057-27677256 Neighboring gene intraflagellar transport 172 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27681686-27682885 Neighboring gene RNA, U6 small nuclear 986, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nuclear receptor binding protein 1 (NRBP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with NRBP1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ27109, FLJ35541

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
nuclear receptor-binding protein
Names
multiple domain putative nuclear protein
myeloid leukemia factor 1 adaptor molecule

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321357.2NP_001308286.1  nuclear receptor-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074117, AK122664, BC001221
    Consensus CDS
    CCDS1753.1
    UniProtKB/Swiss-Prot
    B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
    UniProtKB/TrEMBL
    B4DW31
    Related
    ENSP00000233557.3, ENST00000233557.7
    Conserved Domains (1) summary
    cd14034
    Location:60334
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
  2. NM_001321358.2NP_001308287.1  nuclear receptor-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    Consensus CDS
    CCDS82433.1
    UniProtKB/TrEMBL
    B4DW31, F8W6G1
    Conserved Domains (1) summary
    cd14034
    Location:60342
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
  3. NM_001321359.2NP_001308288.1  nuclear receptor-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    Consensus CDS
    CCDS82433.1
    UniProtKB/TrEMBL
    B4DW31, F8W6G1
    Related
    ENSP00000369192.3, ENST00000379863.7
    Conserved Domains (1) summary
    cd14034
    Location:60342
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
  4. NM_001321361.2NP_001308290.1  nuclear receptor-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    UniProtKB/TrEMBL
    B4DW31
    Conserved Domains (2) summary
    smart00220
    Location:83332
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14034
    Location:60341
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
  5. NM_001321362.2NP_001308291.1  nuclear receptor-binding protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    UniProtKB/TrEMBL
    B4DW31
    Conserved Domains (1) summary
    cd14034
    Location:60333
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
  6. NM_001321363.2NP_001308292.1  nuclear receptor-binding protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC074117, BC001221
    UniProtKB/TrEMBL
    B4DW31
    Conserved Domains (1) summary
    cl21453
    Location:60302
    PKc_like; Protein Kinases, catalytic domain
  7. NM_013392.4NP_037524.1  nuclear receptor-binding protein isoform 1

    See identical proteins and their annotated locations for NP_037524.1

    Status: VALIDATED

    Source sequence(s)
    BC001221, BQ949042
    Consensus CDS
    CCDS1753.1
    UniProtKB/Swiss-Prot
    B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
    UniProtKB/TrEMBL
    B4DW31
    Related
    ENSP00000369181.3, ENST00000379852.8
    Conserved Domains (1) summary
    cd14034
    Location:60334
    PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    27427790..27442259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444036.1XP_047299992.1  nuclear receptor-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
    UniProtKB/TrEMBL
    B4DW31

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    27470161..27484612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341567.1XP_054197542.1  nuclear receptor-binding protein isoform X1

    UniProtKB/Swiss-Prot
    B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
    UniProtKB/TrEMBL
    B4DW31